Rescue of the MERTK phagocytic defect in a human iPSC disease model using translational read-through inducing drugs

Rescue of the MERTK phagocytic defect in a human iPSC disease model using translational read-through inducing drugs

Abstract Inherited retinal dystrophies are an important cause of blindness, for which currently there are no effective treatments. In order to study this heterogeneous group of diseases, adequate disease models are required in order to better understand pathology and to test potential therapies. Ind...

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Autores principales: Conor M. Ramsden, Britta Nommiste, Amelia R. Lane, Amanda-Jayne F. Carr, Michael B. Powner, Matthew J. K. Smart, Li Li Chen, Manickam N. Muthiah, Andrew R. Webster, Anthony T. Moore, Michael E. Cheetham, Lyndon da Cruz, Peter J. Coffey
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/2c6bb3edda1a42e7b46f27b3e51b9e86
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https://doaj.org/article/2c6bb3edda1a42e7b46f27b3e51b9e86

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