Constrained G4 structures unveil topology specificity of known and new G4 binding proteins

Abstract G-quadruplexes (G4) are non-canonical secondary structures consisting in stacked tetrads of hydrogen-bonded guanines bases. An essential feature of G4 is their intrinsic polymorphic nature, which is characterized by the equilibrium between several conformations (also called topologies) and...

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Autores principales: A. Pipier, A. Devaux, T. Lavergne, A. Adrait, Y. Couté, S. Britton, P. Calsou, J. F. Riou, E. Defrancq, D. Gomez
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2c988d23c216412e911662ca68f6596a
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