Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation

Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation

Invadosomes degrade extracellular matrix and facilitate cell invasion but their molecular composition is not fully understood. Here, the authors combine laser capture and mass spectrometry to map the proteome of invadosomes, showing that they rely on internal translational activity to maintain their...

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Main Authors: Zakaria Ezzoukhry, Elodie Henriet, Fabrice P. Cordelières, Jean-William Dupuy, Marlène Maître, Nathan Gay, Sylvaine Di-Tommaso, Luc Mercier, Jacky G. Goetz, Marion Peter, Frédéric Bard, Violaine Moreau, Anne-Aurélie Raymond, Frédéric Saltel
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/2c995818d6d044ceb85f3e411b0ea6e8
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Summary:Invadosomes degrade extracellular matrix and facilitate cell invasion but their molecular composition is not fully understood. Here, the authors combine laser capture and mass spectrometry to map the proteome of invadosomes, showing that they rely on internal translational activity to maintain their structure.

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