A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT

The Pseudomonas putida toxin GraT and antitoxin GraA form a type II toxin-antoxin module. Here the authors present the crystal structures of the GraA dimer, GraTA and GraA-DNA complexes and show that GraT contains a functionally important N-terminal intrinsic disordered region that prevents the bind...

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Autores principales:	Ariel Talavera, Hedvig Tamman, Andres Ainelo, Albert Konijnenberg, San Hadži, Frank Sobott, Abel Garcia-Pino, Rita Hõrak, Remy Loris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ca47fc86554403caf82746cade3eeed
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spelling	oai:doaj.org-article:2ca47fc86554403caf82746cade3eeed2021-12-02T14:38:38ZA dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT10.1038/s41467-019-08865-z2041-1723https://doaj.org/article/2ca47fc86554403caf82746cade3eeed2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08865-zhttps://doaj.org/toc/2041-1723The Pseudomonas putida toxin GraT and antitoxin GraA form a type II toxin-antoxin module. Here the authors present the crystal structures of the GraA dimer, GraTA and GraA-DNA complexes and show that GraT contains a functionally important N-terminal intrinsic disordered region that prevents the binding of the GraTA complex to the operator.Ariel TalaveraHedvig TammanAndres AineloAlbert KonijnenbergSan HadžiFrank SobottAbel Garcia-PinoRita HõrakRemy LorisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ariel Talavera Hedvig Tamman Andres Ainelo Albert Konijnenberg San Hadži Frank Sobott Abel Garcia-Pino Rita Hõrak Remy Loris A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT
description	The Pseudomonas putida toxin GraT and antitoxin GraA form a type II toxin-antoxin module. Here the authors present the crystal structures of the GraA dimer, GraTA and GraA-DNA complexes and show that GraT contains a functionally important N-terminal intrinsic disordered region that prevents the binding of the GraTA complex to the operator.
format	article
author	Ariel Talavera Hedvig Tamman Andres Ainelo Albert Konijnenberg San Hadži Frank Sobott Abel Garcia-Pino Rita Hõrak Remy Loris
author_facet	Ariel Talavera Hedvig Tamman Andres Ainelo Albert Konijnenberg San Hadži Frank Sobott Abel Garcia-Pino Rita Hõrak Remy Loris
author_sort	Ariel Talavera
title	A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT
title_short	A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT
title_full	A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT
title_fullStr	A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT
title_full_unstemmed	A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT
title_sort	dual role in regulation and toxicity for the disordered n-terminus of the toxin grat
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2ca47fc86554403caf82746cade3eeed
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A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT

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