Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure

The genetic and pathogenetic basis of heart failure is incompletely understood. Here, the authors present a high-fidelity tissue collection from rapidly preserved failing and non-failing control hearts which are used for eQTL mapping and network analysis, resulting in the prioritization of PPP1R3A a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pablo Cordero, Victoria N. Parikh, Elizabeth T. Chin, Ayca Erbilgin, Michael J. Gloudemans, Ching Shang, Yong Huang, Alex C. Chang, Kevin S. Smith, Frederick Dewey, Kathia Zaleta, Michael Morley, Jeff Brandimarto, Nicole Glazer, Daryl Waggott, Aleksandra Pavlovic, Mingming Zhao, Christine S. Moravec, W. H. Wilson Tang, Jamie Skreen, Christine Malloy, Sridhar Hannenhalli, Hongzhe Li, Scott Ritter, Mingyao Li, Daniel Bernstein, Andrew Connolly, Hakon Hakonarson, Aldons J. Lusis, Kenneth B. Margulies, Anna A. Depaoli-Roach, Stephen B. Montgomery, Matthew T. Wheeler, Thomas Cappola, Euan A. Ashley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ca5a8edf42d48a4acecfce1aa70adac
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2ca5a8edf42d48a4acecfce1aa70adac
record_format	dspace
spelling	oai:doaj.org-article:2ca5a8edf42d48a4acecfce1aa70adac2021-12-02T16:58:03ZPathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure10.1038/s41467-019-10591-52041-1723https://doaj.org/article/2ca5a8edf42d48a4acecfce1aa70adac2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10591-5https://doaj.org/toc/2041-1723The genetic and pathogenetic basis of heart failure is incompletely understood. Here, the authors present a high-fidelity tissue collection from rapidly preserved failing and non-failing control hearts which are used for eQTL mapping and network analysis, resulting in the prioritization of PPP1R3A as a heart failure gene.Pablo CorderoVictoria N. ParikhElizabeth T. ChinAyca ErbilginMichael J. GloudemansChing ShangYong HuangAlex C. ChangKevin S. SmithFrederick DeweyKathia ZaletaMichael MorleyJeff BrandimartoNicole GlazerDaryl WaggottAleksandra PavlovicMingming ZhaoChristine S. MoravecW. H. Wilson TangJamie SkreenChristine MalloySridhar HannenhalliHongzhe LiScott RitterMingyao LiDaniel BernsteinAndrew ConnollyHakon HakonarsonAldons J. LusisKenneth B. MarguliesAnna A. Depaoli-RoachStephen B. MontgomeryMatthew T. WheelerThomas CappolaEuan A. AshleyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pablo Cordero Victoria N. Parikh Elizabeth T. Chin Ayca Erbilgin Michael J. Gloudemans Ching Shang Yong Huang Alex C. Chang Kevin S. Smith Frederick Dewey Kathia Zaleta Michael Morley Jeff Brandimarto Nicole Glazer Daryl Waggott Aleksandra Pavlovic Mingming Zhao Christine S. Moravec W. H. Wilson Tang Jamie Skreen Christine Malloy Sridhar Hannenhalli Hongzhe Li Scott Ritter Mingyao Li Daniel Bernstein Andrew Connolly Hakon Hakonarson Aldons J. Lusis Kenneth B. Margulies Anna A. Depaoli-Roach Stephen B. Montgomery Matthew T. Wheeler Thomas Cappola Euan A. Ashley Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure
description	The genetic and pathogenetic basis of heart failure is incompletely understood. Here, the authors present a high-fidelity tissue collection from rapidly preserved failing and non-failing control hearts which are used for eQTL mapping and network analysis, resulting in the prioritization of PPP1R3A as a heart failure gene.
format	article
author	Pablo Cordero Victoria N. Parikh Elizabeth T. Chin Ayca Erbilgin Michael J. Gloudemans Ching Shang Yong Huang Alex C. Chang Kevin S. Smith Frederick Dewey Kathia Zaleta Michael Morley Jeff Brandimarto Nicole Glazer Daryl Waggott Aleksandra Pavlovic Mingming Zhao Christine S. Moravec W. H. Wilson Tang Jamie Skreen Christine Malloy Sridhar Hannenhalli Hongzhe Li Scott Ritter Mingyao Li Daniel Bernstein Andrew Connolly Hakon Hakonarson Aldons J. Lusis Kenneth B. Margulies Anna A. Depaoli-Roach Stephen B. Montgomery Matthew T. Wheeler Thomas Cappola Euan A. Ashley
author_facet	Pablo Cordero Victoria N. Parikh Elizabeth T. Chin Ayca Erbilgin Michael J. Gloudemans Ching Shang Yong Huang Alex C. Chang Kevin S. Smith Frederick Dewey Kathia Zaleta Michael Morley Jeff Brandimarto Nicole Glazer Daryl Waggott Aleksandra Pavlovic Mingming Zhao Christine S. Moravec W. H. Wilson Tang Jamie Skreen Christine Malloy Sridhar Hannenhalli Hongzhe Li Scott Ritter Mingyao Li Daniel Bernstein Andrew Connolly Hakon Hakonarson Aldons J. Lusis Kenneth B. Margulies Anna A. Depaoli-Roach Stephen B. Montgomery Matthew T. Wheeler Thomas Cappola Euan A. Ashley
author_sort	Pablo Cordero
title	Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure
title_short	Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure
title_full	Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure
title_fullStr	Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure
title_full_unstemmed	Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure
title_sort	pathologic gene network rewiring implicates ppp1r3a as a central regulator in pressure overload heart failure
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2ca5a8edf42d48a4acecfce1aa70adac
work_keys_str_mv	AT pablocordero pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT victorianparikh pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT elizabethtchin pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT aycaerbilgin pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT michaeljgloudemans pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT chingshang pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT yonghuang pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT alexcchang pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT kevinssmith pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT frederickdewey pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT kathiazaleta pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT michaelmorley pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT jeffbrandimarto pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT nicoleglazer pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT darylwaggott pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT aleksandrapavlovic pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT mingmingzhao pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT christinesmoravec pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT whwilsontang pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT jamieskreen pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT christinemalloy pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT sridharhannenhalli pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT hongzheli pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT scottritter pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT mingyaoli pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT danielbernstein pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT andrewconnolly pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT hakonhakonarson pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT aldonsjlusis pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT kennethbmargulies pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT annaadepaoliroach pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT stephenbmontgomery pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT matthewtwheeler pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT thomascappola pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure AT euanaashley pathologicgenenetworkrewiringimplicatesppp1r3aasacentralregulatorinpressureoverloadheartfailure
_version_	1718382378212130816

Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure

Ejemplares similares