Real-time imaging of intestinal bacterial β-glucuronidase activity by hydrolysis of a fluorescent probe

Abstract Intestinal bacterial β-glucuronidase (βG) hydrolyzes glucuronidated metabolites to their toxic form in intestines, resulting in intestinal damage. The development of a method to inhibit βG is thus important but has been limited by the difficulty of directly assessing enzyme activity in live...

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Autores principales: Michael Chen, Kai-Wen Cheng, Yi-Jou Chen, Chang-Hung Wang, Ta-Chun Cheng, Kuo-Chien Chang, An-Pei Kao, Kuo-Hsiang Chuang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/2d0f1bd83aa0414da3acd81e41ce2509
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