Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

Ketamine exerts fast-acting anti-depressant responses. Here the authors show that dopamine D1 receptor expressing neurons in the medial prefrontal cortex contribute to these antidepressant-like effects in mice.

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Autores principales:	Brendan D. Hare, Ryota Shinohara, Rong Jian Liu, Santosh Pothula, Ralph J. DiLeone, Ronald S. Duman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d3337a5795543eab74014329bf3aa23
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spelling	oai:doaj.org-article:2d3337a5795543eab74014329bf3aa232021-12-02T14:40:17ZOptogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects10.1038/s41467-018-08168-92041-1723https://doaj.org/article/2d3337a5795543eab74014329bf3aa232019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08168-9https://doaj.org/toc/2041-1723Ketamine exerts fast-acting anti-depressant responses. Here the authors show that dopamine D1 receptor expressing neurons in the medial prefrontal cortex contribute to these antidepressant-like effects in mice.Brendan D. HareRyota ShinoharaRong Jian LiuSantosh PothulaRalph J. DiLeoneRonald S. DumanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brendan D. Hare Ryota Shinohara Rong Jian Liu Santosh Pothula Ralph J. DiLeone Ronald S. Duman Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects
description	Ketamine exerts fast-acting anti-depressant responses. Here the authors show that dopamine D1 receptor expressing neurons in the medial prefrontal cortex contribute to these antidepressant-like effects in mice.
format	article
author	Brendan D. Hare Ryota Shinohara Rong Jian Liu Santosh Pothula Ralph J. DiLeone Ronald S. Duman
author_facet	Brendan D. Hare Ryota Shinohara Rong Jian Liu Santosh Pothula Ralph J. DiLeone Ronald S. Duman
author_sort	Brendan D. Hare
title	Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects
title_short	Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects
title_full	Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects
title_fullStr	Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects
title_full_unstemmed	Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects
title_sort	optogenetic stimulation of medial prefrontal cortex drd1 neurons produces rapid and long-lasting antidepressant effects
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2d3337a5795543eab74014329bf3aa23
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Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

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