High-performance chemical- and light-inducible recombinases in mammalian cells and mice

The availability of high performance recombinases with low basal activity and high dynamic range is limited. Here the authors present a library of over 20 orthogonal split recombinases that can be induced by small molecules, light and temperature in vivo.

Guardado en:

Detalles Bibliográficos
Autores principales:	Benjamin H. Weinberg, Jang Hwan Cho, Yash Agarwal, N. T. Hang Pham, Leidy D. Caraballo, Maciej Walkosz, Charina Ortega, Micaela Trexler, Nathan Tague, Billy Law, William K. J. Benman, Justin Letendre, Jacob Beal, Wilson W. Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d4222928cd84b6aa52fbca43ee615fa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2d4222928cd84b6aa52fbca43ee615fa
record_format	dspace
spelling	oai:doaj.org-article:2d4222928cd84b6aa52fbca43ee615fa2021-12-02T16:58:27ZHigh-performance chemical- and light-inducible recombinases in mammalian cells and mice10.1038/s41467-019-12800-72041-1723https://doaj.org/article/2d4222928cd84b6aa52fbca43ee615fa2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12800-7https://doaj.org/toc/2041-1723The availability of high performance recombinases with low basal activity and high dynamic range is limited. Here the authors present a library of over 20 orthogonal split recombinases that can be induced by small molecules, light and temperature in vivo.Benjamin H. WeinbergJang Hwan ChoYash AgarwalN. T. Hang PhamLeidy D. CaraballoMaciej WalkoszCharina OrtegaMicaela TrexlerNathan TagueBilly LawWilliam K. J. BenmanJustin LetendreJacob BealWilson W. WongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin H. Weinberg Jang Hwan Cho Yash Agarwal N. T. Hang Pham Leidy D. Caraballo Maciej Walkosz Charina Ortega Micaela Trexler Nathan Tague Billy Law William K. J. Benman Justin Letendre Jacob Beal Wilson W. Wong High-performance chemical- and light-inducible recombinases in mammalian cells and mice
description	The availability of high performance recombinases with low basal activity and high dynamic range is limited. Here the authors present a library of over 20 orthogonal split recombinases that can be induced by small molecules, light and temperature in vivo.
format	article
author	Benjamin H. Weinberg Jang Hwan Cho Yash Agarwal N. T. Hang Pham Leidy D. Caraballo Maciej Walkosz Charina Ortega Micaela Trexler Nathan Tague Billy Law William K. J. Benman Justin Letendre Jacob Beal Wilson W. Wong
author_facet	Benjamin H. Weinberg Jang Hwan Cho Yash Agarwal N. T. Hang Pham Leidy D. Caraballo Maciej Walkosz Charina Ortega Micaela Trexler Nathan Tague Billy Law William K. J. Benman Justin Letendre Jacob Beal Wilson W. Wong
author_sort	Benjamin H. Weinberg
title	High-performance chemical- and light-inducible recombinases in mammalian cells and mice
title_short	High-performance chemical- and light-inducible recombinases in mammalian cells and mice
title_full	High-performance chemical- and light-inducible recombinases in mammalian cells and mice
title_fullStr	High-performance chemical- and light-inducible recombinases in mammalian cells and mice
title_full_unstemmed	High-performance chemical- and light-inducible recombinases in mammalian cells and mice
title_sort	high-performance chemical- and light-inducible recombinases in mammalian cells and mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2d4222928cd84b6aa52fbca43ee615fa
work_keys_str_mv	AT benjaminhweinberg highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice AT janghwancho highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice AT yashagarwal highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice AT nthangpham highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice AT leidydcaraballo highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice AT maciejwalkosz highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice AT charinaortega highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice AT micaelatrexler highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice AT nathantague highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice AT billylaw highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice AT williamkjbenman highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice AT justinletendre highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice AT jacobbeal highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice AT wilsonwwong highperformancechemicalandlightinduciblerecombinasesinmammaliancellsandmice
_version_	1718382317777453056

High-performance chemical- and light-inducible recombinases in mammalian cells and mice

Ejemplares similares