Covalent Modification of Bacteriophage T4 DNA Inhibits CRISPR-Cas9

ABSTRACT The genomic DNAs of tailed bacteriophages are commonly modified by the attachment of chemical groups. Some forms of DNA modification are known to protect phage DNA from cleavage by restriction enzymes, but others are of unknown function. Recently, the CRISPR-Cas nuclease complexes were show...

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Autores principales: Alexandra L. Bryson, Young Hwang, Scott Sherrill-Mix, Gary D. Wu, James D. Lewis, Lindsay Black, Tyson A. Clark, Frederic D. Bushman
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2015
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Acceso en línea:https://doaj.org/article/2d549af73f85431d9cd2431ee86d1e36
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