Covalent Modification of Bacteriophage T4 DNA Inhibits CRISPR-Cas9

ABSTRACT The genomic DNAs of tailed bacteriophages are commonly modified by the attachment of chemical groups. Some forms of DNA modification are known to protect phage DNA from cleavage by restriction enzymes, but others are of unknown function. Recently, the CRISPR-Cas nuclease complexes were show...

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Auteurs principaux: Alexandra L. Bryson, Young Hwang, Scott Sherrill-Mix, Gary D. Wu, James D. Lewis, Lindsay Black, Tyson A. Clark, Frederic D. Bushman
Format: article
Langue:EN
Publié: American Society for Microbiology 2015
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Accès en ligne:https://doaj.org/article/2d549af73f85431d9cd2431ee86d1e36
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