Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses

IL-27 is one of a number of cytokines that can induce antitumour CD8+ T cell responses. Here the authors show that TTP, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.

Guardado en:
Detalles Bibliográficos
Autores principales: Qinghong Wang, Huan Ning, Hui Peng, Lin Wei, Rong Hou, Daniel F. Hoft, Jianguo Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/2d64b6674fe54f428ac2534371126ffd
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!