Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses

IL-27 is one of a number of cytokines that can induce antitumour CD8+ T cell responses. Here the authors show that TTP, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.

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Bibliographic Details
Main Authors: Qinghong Wang, Huan Ning, Hui Peng, Lin Wei, Rong Hou, Daniel F. Hoft, Jianguo Liu
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/2d64b6674fe54f428ac2534371126ffd
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