Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses

IL-27 is one of a number of cytokines that can induce antitumour CD8+ T cell responses. Here the authors show that TTP, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.

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Autores principales:	Qinghong Wang, Huan Ning, Hui Peng, Lin Wei, Rong Hou, Daniel F. Hoft, Jianguo Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d64b6674fe54f428ac2534371126ffd
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spelling	oai:doaj.org-article:2d64b6674fe54f428ac2534371126ffd2021-12-02T14:42:33ZTristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses10.1038/s41467-017-00892-y2041-1723https://doaj.org/article/2d64b6674fe54f428ac2534371126ffd2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00892-yhttps://doaj.org/toc/2041-1723IL-27 is one of a number of cytokines that can induce antitumour CD8+ T cell responses. Here the authors show that TTP, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.Qinghong WangHuan NingHui PengLin WeiRong HouDaniel F. HoftJianguo LiuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qinghong Wang Huan Ning Hui Peng Lin Wei Rong Hou Daniel F. Hoft Jianguo Liu Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses
description	IL-27 is one of a number of cytokines that can induce antitumour CD8+ T cell responses. Here the authors show that TTP, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.
format	article
author	Qinghong Wang Huan Ning Hui Peng Lin Wei Rong Hou Daniel F. Hoft Jianguo Liu
author_facet	Qinghong Wang Huan Ning Hui Peng Lin Wei Rong Hou Daniel F. Hoft Jianguo Liu
author_sort	Qinghong Wang
title	Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses
title_short	Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses
title_full	Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses
title_fullStr	Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses
title_full_unstemmed	Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses
title_sort	tristetraprolin inhibits macrophage il-27-induced activation of antitumour cytotoxic t cell responses
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2d64b6674fe54f428ac2534371126ffd
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Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses

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