CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells

T cell bystander activation is induced by systemic inflammation. Here the authors show, using mouse model systems and correlating with human vaccination data, that localized inflammation elicits bystander activation, and that CXCR3 specifically recruits memory CD8+ T cells to sites of activated anti...

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Autores principales:	Nicholas J. Maurice, M. Juliana McElrath, Erica Andersen-Nissen, Nicole Frahm, Martin Prlic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2da069aa679845dc876812190e0373ee
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spelling	oai:doaj.org-article:2da069aa679845dc876812190e0373ee2021-12-02T17:32:25ZCXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells10.1038/s41467-019-12980-22041-1723https://doaj.org/article/2da069aa679845dc876812190e0373ee2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12980-2https://doaj.org/toc/2041-1723T cell bystander activation is induced by systemic inflammation. Here the authors show, using mouse model systems and correlating with human vaccination data, that localized inflammation elicits bystander activation, and that CXCR3 specifically recruits memory CD8+ T cells to sites of activated antigen-presenting cells for bystander activation.Nicholas J. MauriceM. Juliana McElrathErica Andersen-NissenNicole FrahmMartin PrlicNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas J. Maurice M. Juliana McElrath Erica Andersen-Nissen Nicole Frahm Martin Prlic CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells
description	T cell bystander activation is induced by systemic inflammation. Here the authors show, using mouse model systems and correlating with human vaccination data, that localized inflammation elicits bystander activation, and that CXCR3 specifically recruits memory CD8+ T cells to sites of activated antigen-presenting cells for bystander activation.
format	article
author	Nicholas J. Maurice M. Juliana McElrath Erica Andersen-Nissen Nicole Frahm Martin Prlic
author_facet	Nicholas J. Maurice M. Juliana McElrath Erica Andersen-Nissen Nicole Frahm Martin Prlic
author_sort	Nicholas J. Maurice
title	CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells
title_short	CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells
title_full	CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells
title_fullStr	CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells
title_full_unstemmed	CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells
title_sort	cxcr3 enables recruitment and site-specific bystander activation of memory cd8+ t cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2da069aa679845dc876812190e0373ee
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CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells

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