Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-<sc>d</sc>-Glucan Synthase Cause Clinically Important Echinocandin Resistance in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>

Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-<sc>d</sc>-Glucan Synthase Cause Clinically Important Echinocandin Resistance in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>

ABSTRACT Aspergillus fumigatus is a leading cause of invasive fungal infections. Resistance to first-line triazole antifungals has led to therapy with echinocandin drugs. Recently, we identified several high-minimum-effective-concentration (MEC) A. fumigatus clinical isolates from patients failing e...

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Bibliographic Details
Main Authors: Shruthi Satish, Cristina Jiménez-Ortigosa, Yanan Zhao, Min Hee Lee, Enriko Dolgov, Thomas Krüger, Steven Park, David W. Denning, Olaf Kniemeyer, Axel A. Brakhage, David S. Perlin
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
Aspergillus fumigatus
ROS
antifungal resistance
caspofungin
echinocandins
glucan synthase
Microbiology
QR1-502
Online Access:https://doaj.org/article/2dcc72bc71854ea8b9eab4d51ffbbb11
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https://doaj.org/article/2dcc72bc71854ea8b9eab4d51ffbbb11

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