Integrating continuous hypermutation with high‐throughput screening for optimization of cis,cis‐muconic acid production in yeast

Summary Directed evolution is a powerful method to optimize proteins and metabolic reactions towards user‐defined goals. It usually involves subjecting genes or pathways to iterative rounds of mutagenesis, selection and amplification. While powerful, systematic searches through large sequence‐spaces...

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Autores principales: Emil D. Jensen, Francesca Ambri, Marie B. Bendtsen, Alex A. Javanpour, Chang C. Liu, Michael K. Jensen, Jay D. Keasling
Formato: article
Lenguaje:EN
Publicado: Wiley 2021
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Acceso en línea:https://doaj.org/article/2dcfe0c268f74d13888f38a9b161fae9
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