The Pseudokinase TRIB3 Negatively Regulates the HER2 Receptor Pathway and Is a Biomarker of Good Prognosis in Luminal Breast Cancer

The Pseudokinase TRIB3 Negatively Regulates the HER2 Receptor Pathway and Is a Biomarker of Good Prognosis in Luminal Breast Cancer

Background: Tribbles pseudokinase 3 (TRIB3) has been proposed to both promote and restrict cancer generation and progression. However, the precise mechanisms that determine this dual role of TRIB3 in cancer remain to be understood. In this study we aimed to investigate the role of TRIB3 in luminal b...

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Autores principales: Alba Orea-Soufi, Sonia Castillo-Lluva, Nélida Salvador-Tormo, Paola Martín-Cabrera, Silvia Recuero, Estíbaliz Gabicagogeascoa, Manuel Moreno-Valladares, Marina Mendiburu-Eliçabe, Adrián Blanco-Gómez, José Miguel Ramos-Pittol, Elena García-Taboada, Alberto Ocaña, Francisco J. Cimas, Ander Matheu, Isabel Álvarez-López, Guillermo Velasco, Mar Lorente
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
TRIB3
Luminal breast cancer
HER2
AKT
tissue microarrays
cell signaling
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/2ddfb020abf5403b9f645cb2a10c2e8d
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https://doaj.org/article/2ddfb020abf5403b9f645cb2a10c2e8d

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