Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks

Mendelian randomization is a popular method to detect causal relationships between traits, but can be confounded by instances of horizontal pleiotropy. Here, the authors present a Mendelian randomization workflow which includes causal discovery analysis and filtering of genetic instruments based on...

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Autores principales: David Amar, Nasa Sinnott-Armstrong, Euan A. Ashley, Manuel A. Rivas
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2de5d6dbd2ae49f294dc1e672035ea20
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