Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives

Selective para-functionalization of substituted arenes is a formidable challenge in homogeneous catalysis. Here, the authors achieved the para-selective C-H difluoromethylation of anilides, indolines and tetrahydroquinolines with a ruthenium catalyst in good yields and apply it to the synthesis of b...

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Autores principales:	Chunchen Yuan, Lei Zhu, Changpeng Chen, Xiaolan Chen, Yong Yang, Yu Lan, Yingsheng Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2e010d01252e4fb4a3b57e589263ff4a
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spelling	oai:doaj.org-article:2e010d01252e4fb4a3b57e589263ff4a2021-12-02T15:34:45ZRuthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives10.1038/s41467-018-03341-62041-1723https://doaj.org/article/2e010d01252e4fb4a3b57e589263ff4a2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03341-6https://doaj.org/toc/2041-1723Selective para-functionalization of substituted arenes is a formidable challenge in homogeneous catalysis. Here, the authors achieved the para-selective C-H difluoromethylation of anilides, indolines and tetrahydroquinolines with a ruthenium catalyst in good yields and apply it to the synthesis of bioactive compounds.Chunchen YuanLei ZhuChangpeng ChenXiaolan ChenYong YangYu LanYingsheng ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chunchen Yuan Lei Zhu Changpeng Chen Xiaolan Chen Yong Yang Yu Lan Yingsheng Zhao Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives
description	Selective para-functionalization of substituted arenes is a formidable challenge in homogeneous catalysis. Here, the authors achieved the para-selective C-H difluoromethylation of anilides, indolines and tetrahydroquinolines with a ruthenium catalyst in good yields and apply it to the synthesis of bioactive compounds.
format	article
author	Chunchen Yuan Lei Zhu Changpeng Chen Xiaolan Chen Yong Yang Yu Lan Yingsheng Zhao
author_facet	Chunchen Yuan Lei Zhu Changpeng Chen Xiaolan Chen Yong Yang Yu Lan Yingsheng Zhao
author_sort	Chunchen Yuan
title	Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives
title_short	Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives
title_full	Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives
title_fullStr	Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives
title_full_unstemmed	Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives
title_sort	ruthenium(ii)-enabled para-selective c–h difluoromethylation of anilides and their derivatives
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2e010d01252e4fb4a3b57e589263ff4a
work_keys_str_mv	AT chunchenyuan rutheniumiienabledparaselectivechdifluoromethylationofanilidesandtheirderivatives AT leizhu rutheniumiienabledparaselectivechdifluoromethylationofanilidesandtheirderivatives AT changpengchen rutheniumiienabledparaselectivechdifluoromethylationofanilidesandtheirderivatives AT xiaolanchen rutheniumiienabledparaselectivechdifluoromethylationofanilidesandtheirderivatives AT yongyang rutheniumiienabledparaselectivechdifluoromethylationofanilidesandtheirderivatives AT yulan rutheniumiienabledparaselectivechdifluoromethylationofanilidesandtheirderivatives AT yingshengzhao rutheniumiienabledparaselectivechdifluoromethylationofanilidesandtheirderivatives
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Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives

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