R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature

Formation of the vascular lumen initiates the blood flow and it is crucial for tissue homeostasis. Here, Li et. al show that the R-Ras-Akt signaling axis is crucial for reparative angiogenesis in mice because it stabilizes the microtubule cytoskeleton in endothelial cells to promote endothelial lume...

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Autores principales:	Fangfei Li, Junko Sawada, Masanobu Komatsu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2e089150929e47c5bc3c05ddcd89b791
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spelling	oai:doaj.org-article:2e089150929e47c5bc3c05ddcd89b7912021-12-02T14:40:25ZR-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature10.1038/s41467-017-01865-x2041-1723https://doaj.org/article/2e089150929e47c5bc3c05ddcd89b7912017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01865-xhttps://doaj.org/toc/2041-1723Formation of the vascular lumen initiates the blood flow and it is crucial for tissue homeostasis. Here, Li et. al show that the R-Ras-Akt signaling axis is crucial for reparative angiogenesis in mice because it stabilizes the microtubule cytoskeleton in endothelial cells to promote endothelial lumen formation.Fangfei LiJunko SawadaMasanobu KomatsuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fangfei Li Junko Sawada Masanobu Komatsu R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature
description	Formation of the vascular lumen initiates the blood flow and it is crucial for tissue homeostasis. Here, Li et. al show that the R-Ras-Akt signaling axis is crucial for reparative angiogenesis in mice because it stabilizes the microtubule cytoskeleton in endothelial cells to promote endothelial lumen formation.
format	article
author	Fangfei Li Junko Sawada Masanobu Komatsu
author_facet	Fangfei Li Junko Sawada Masanobu Komatsu
author_sort	Fangfei Li
title	R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature
title_short	R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature
title_full	R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature
title_fullStr	R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature
title_full_unstemmed	R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature
title_sort	r-ras-akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2e089150929e47c5bc3c05ddcd89b791
work_keys_str_mv	AT fangfeili rrasaktaxisinducesendotheliallumenogenesisandregulatesthepatencyofregeneratingvasculature AT junkosawada rrasaktaxisinducesendotheliallumenogenesisandregulatesthepatencyofregeneratingvasculature AT masanobukomatsu rrasaktaxisinducesendotheliallumenogenesisandregulatesthepatencyofregeneratingvasculature
_version_	1718390286016577536

R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature

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