The C-Circle Biomarker Is Secreted by Alternative-Lengthening-of-Telomeres Positive Cancer Cells inside Exosomes and Provides a Blood-Based Diagnostic for ALT Activity

The C-Circle Biomarker Is Secreted by Alternative-Lengthening-of-Telomeres Positive Cancer Cells inside Exosomes and Provides a Blood-Based Diagnostic for ALT Activity

C-Circles, self-primed telomeric C-strand templates for rolling circle amplification, are the only known alternative-lengthening-of-telomeres (ALT)-specific molecule. However, little is known about the biology of C-Circles and if they may be clinically useful. Here we show that C-Circles are secrete...

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Bibliographic Details
Main Authors: Yuan-Yin Chen, Rebecca Dagg, Yuchen Zhang, Joyce H. Y. Lee, Robert Lu, Nancy Martin La Rotta, Sandra Sampl, Medina Korkut-Demirbaş, Klaus Holzmann, Loretta M. S. Lau, Roger R. Reddel, Jeremy D. Henson
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
C-Circle Assay
ALT
telomere
telomere maintenance mechanism
exosomes
cancer diagnostic
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/2e1a777d525147f5857208e90642aece
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https://doaj.org/article/2e1a777d525147f5857208e90642aece

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