“Ryanopathies” and RyR2 dysfunctions: can we further decipher them using in vitro human disease models?

Abstract The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular calcium release channel located on the sarco/endoplasmic reticulum (SR/ER), plays a key role in the intracellula...

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Bibliographic Details
Main Authors: Yvonne Sleiman, Alain Lacampagne, Albano C. Meli
Format: article
Language:EN
Published: Nature Publishing Group 2021
Subjects:
Online Access:https://doaj.org/article/2e323332603b40fba9c18bbfb2a854fd
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