Gene gain and loss push prokaryotes beyond the homologous recombination barrier and accelerate genome sequence divergence

A significant proportion of the molecular evolution of bacteria and archaea occurs through gene gain and loss. Here Iranzo et al. develop a mathematical model that explains observed differential patterns of sequence evolution vs. gene content evolution as a consequence of homologous recombination.

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Bibliographic Details
Main Authors: Jaime Iranzo, Yuri I. Wolf, Eugene V. Koonin, Itamar Sela
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/2e34e7568f784b5ab91d25990d7ba4e6
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Summary:A significant proportion of the molecular evolution of bacteria and archaea occurs through gene gain and loss. Here Iranzo et al. develop a mathematical model that explains observed differential patterns of sequence evolution vs. gene content evolution as a consequence of homologous recombination.