Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway

Differentiating neurons have an increased requirement for copper than their precursors, but the mechanism of altered copper homoeostasis is not known. Here, Hatori et al. show that neuronal differentiation is accompanied by an increased flux of copper through the secretory pathway, increasing supply...

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Auteurs principaux: Yuta Hatori, Ye Yan, Katharina Schmidt, Eri Furukawa, Nesrin M. Hasan, Nan Yang, Chin-Nung Liu, Shanthini Sockanathan, Svetlana Lutsenko
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/2e3f5d94102348589ea9f1de3dc2fa7f
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