Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway

Differentiating neurons have an increased requirement for copper than their precursors, but the mechanism of altered copper homoeostasis is not known. Here, Hatori et al. show that neuronal differentiation is accompanied by an increased flux of copper through the secretory pathway, increasing supply...

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Autores principales:	Yuta Hatori, Ye Yan, Katharina Schmidt, Eri Furukawa, Nesrin M. Hasan, Nan Yang, Chin-Nung Liu, Shanthini Sockanathan, Svetlana Lutsenko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2e3f5d94102348589ea9f1de3dc2fa7f
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spelling	oai:doaj.org-article:2e3f5d94102348589ea9f1de3dc2fa7f2021-12-02T14:40:11ZNeuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway10.1038/ncomms106402041-1723https://doaj.org/article/2e3f5d94102348589ea9f1de3dc2fa7f2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10640https://doaj.org/toc/2041-1723Differentiating neurons have an increased requirement for copper than their precursors, but the mechanism of altered copper homoeostasis is not known. Here, Hatori et al. show that neuronal differentiation is accompanied by an increased flux of copper through the secretory pathway, increasing supply to copper-dependent enzymes.Yuta HatoriYe YanKatharina SchmidtEri FurukawaNesrin M. HasanNan YangChin-Nung LiuShanthini SockanathanSvetlana LutsenkoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuta Hatori Ye Yan Katharina Schmidt Eri Furukawa Nesrin M. Hasan Nan Yang Chin-Nung Liu Shanthini Sockanathan Svetlana Lutsenko Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway
description	Differentiating neurons have an increased requirement for copper than their precursors, but the mechanism of altered copper homoeostasis is not known. Here, Hatori et al. show that neuronal differentiation is accompanied by an increased flux of copper through the secretory pathway, increasing supply to copper-dependent enzymes.
format	article
author	Yuta Hatori Ye Yan Katharina Schmidt Eri Furukawa Nesrin M. Hasan Nan Yang Chin-Nung Liu Shanthini Sockanathan Svetlana Lutsenko
author_facet	Yuta Hatori Ye Yan Katharina Schmidt Eri Furukawa Nesrin M. Hasan Nan Yang Chin-Nung Liu Shanthini Sockanathan Svetlana Lutsenko
author_sort	Yuta Hatori
title	Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway
title_short	Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway
title_full	Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway
title_fullStr	Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway
title_full_unstemmed	Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway
title_sort	neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2e3f5d94102348589ea9f1de3dc2fa7f
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Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway

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