Insight into the stability of cross-β amyloid fibril from VEALYL short peptide with molecular dynamics simulation.
Amyloid fibrils are found in many fatal neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, type II diabetes, and prion disease. The VEALYL short peptide from insulin has been confirmed to aggregate amyloid-like fibrils. However, the aggregation mechanism of amyloi...
Enregistré dans:
Auteurs principaux: | Wei Ye, Yue Chen, Wei Wang, Qingfen Yu, Yixue Li, Jian Zhang, Hai-Feng Chen |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Public Library of Science (PLoS)
2012
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/2e44d7e4452d4acd9b9d0c3562544a87 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Unfolding of the amyloid β-peptide central helix: mechanistic insights from molecular dynamics simulations.
par: Mika Ito, et autres
Publié: (2011) -
Effects of ligands on unfolding of the amyloid β-peptide central helix: mechanistic insights from molecular dynamics simulations.
par: Mika Ito, et autres
Publié: (2012) -
On the heat stability of amyloid-based biological activity: insights from thermal degradation of insulin fibrils.
par: Weronika Surmacz-Chwedoruk, et autres
Publié: (2014) -
pH-controlled stacking direction of the β-strands in peptide fibrils
par: Wei-Hsuan Tseng, et autres
Publié: (2020) -
Binding, conformational transition and dimerization of amyloid-β peptide on GM1-containing ternary membrane: insights from molecular dynamics simulation.
par: Moutusi Manna, et autres
Publié: (2013)