Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds

The relationship between histopathology, gene expression, and biochemical and mechanical properties of wounds is largely unknown. Here, the authors show that activin A alters wound healing at multiple levels by promoting pro-fibrotic gene expression and matrix deposition, thereby affecting biomechan...

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Autores principales: Mateusz S. Wietecha, Marco Pensalfini, Michael Cangkrama, Bettina Müller, Juyoung Jin, Jürgen Brinckmann, Edoardo Mazza, Sabine Werner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/2e66745780404598b2279a929056766b
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