Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds

The relationship between histopathology, gene expression, and biochemical and mechanical properties of wounds is largely unknown. Here, the authors show that activin A alters wound healing at multiple levels by promoting pro-fibrotic gene expression and matrix deposition, thereby affecting biomechan...

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Autores principales:	Mateusz S. Wietecha, Marco Pensalfini, Michael Cangkrama, Bettina Müller, Juyoung Jin, Jürgen Brinckmann, Edoardo Mazza, Sabine Werner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2e66745780404598b2279a929056766b
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spelling	oai:doaj.org-article:2e66745780404598b2279a929056766b2021-12-02T14:49:16ZActivin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds10.1038/s41467-020-16409-z2041-1723https://doaj.org/article/2e66745780404598b2279a929056766b2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16409-zhttps://doaj.org/toc/2041-1723The relationship between histopathology, gene expression, and biochemical and mechanical properties of wounds is largely unknown. Here, the authors show that activin A alters wound healing at multiple levels by promoting pro-fibrotic gene expression and matrix deposition, thereby affecting biomechanical properties of skin wounds.Mateusz S. WietechaMarco PensalfiniMichael CangkramaBettina MüllerJuyoung JinJürgen BrinckmannEdoardo MazzaSabine WernerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mateusz S. Wietecha Marco Pensalfini Michael Cangkrama Bettina Müller Juyoung Jin Jürgen Brinckmann Edoardo Mazza Sabine Werner Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds
description	The relationship between histopathology, gene expression, and biochemical and mechanical properties of wounds is largely unknown. Here, the authors show that activin A alters wound healing at multiple levels by promoting pro-fibrotic gene expression and matrix deposition, thereby affecting biomechanical properties of skin wounds.
format	article
author	Mateusz S. Wietecha Marco Pensalfini Michael Cangkrama Bettina Müller Juyoung Jin Jürgen Brinckmann Edoardo Mazza Sabine Werner
author_facet	Mateusz S. Wietecha Marco Pensalfini Michael Cangkrama Bettina Müller Juyoung Jin Jürgen Brinckmann Edoardo Mazza Sabine Werner
author_sort	Mateusz S. Wietecha
title	Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds
title_short	Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds
title_full	Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds
title_fullStr	Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds
title_full_unstemmed	Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds
title_sort	activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2e66745780404598b2279a929056766b
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Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds

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