Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets
Mucosal melanomas are challenging to treat partly because so little is known about the genetic drivers underpinning them. Here, the authors perform a genomic landscape analysis of samples collected from three continents, revealing a potential role for CDK4/6 or MEK inhibition in the treatment of the...
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Nature Portfolio
2019
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oai:doaj.org-article:2e6c660727314c7ebfed4a9f82ef05a82021-12-02T16:57:19ZWhole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets10.1038/s41467-019-11107-x2041-1723https://doaj.org/article/2e6c660727314c7ebfed4a9f82ef05a82019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11107-xhttps://doaj.org/toc/2041-1723Mucosal melanomas are challenging to treat partly because so little is known about the genetic drivers underpinning them. Here, the authors perform a genomic landscape analysis of samples collected from three continents, revealing a potential role for CDK4/6 or MEK inhibition in the treatment of the disease.Felicity NewellYan KongJames S. WilmottPeter A. JohanssonPeter M. FergusonChuanliang CuiZhongwu LiStephen H. KazakoffHazel BurkeTristan J. DoddsAnn-Marie PatchKatia NonesVarsha TembePing ShangLouise van der WeydenKim WongOliver HolmesSerigne LoConrad LeonardScott WoodQinying XuRobert V. RawsonPamela MukhopadhyayReinhard DummerMitchell P. LevesqueGöran JönssonXuan WangIwei YehHong WuNancy JosephBoris C. BastianGeorgina V. LongAndrew J. SpillaneKerwin F. ShannonJohn F. ThompsonRobyn P. M. SawDavid J. AdamsLu SiJohn V. PearsonNicholas K. HaywardNicola WaddellGraham J. MannJun GuoRichard A. ScolyerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Felicity Newell Yan Kong James S. Wilmott Peter A. Johansson Peter M. Ferguson Chuanliang Cui Zhongwu Li Stephen H. Kazakoff Hazel Burke Tristan J. Dodds Ann-Marie Patch Katia Nones Varsha Tembe Ping Shang Louise van der Weyden Kim Wong Oliver Holmes Serigne Lo Conrad Leonard Scott Wood Qinying Xu Robert V. Rawson Pamela Mukhopadhyay Reinhard Dummer Mitchell P. Levesque Göran Jönsson Xuan Wang Iwei Yeh Hong Wu Nancy Joseph Boris C. Bastian Georgina V. Long Andrew J. Spillane Kerwin F. Shannon John F. Thompson Robyn P. M. Saw David J. Adams Lu Si John V. Pearson Nicholas K. Hayward Nicola Waddell Graham J. Mann Jun Guo Richard A. Scolyer Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets |
| description |
Mucosal melanomas are challenging to treat partly because so little is known about the genetic drivers underpinning them. Here, the authors perform a genomic landscape analysis of samples collected from three continents, revealing a potential role for CDK4/6 or MEK inhibition in the treatment of the disease. |
| format |
article |
| author |
Felicity Newell Yan Kong James S. Wilmott Peter A. Johansson Peter M. Ferguson Chuanliang Cui Zhongwu Li Stephen H. Kazakoff Hazel Burke Tristan J. Dodds Ann-Marie Patch Katia Nones Varsha Tembe Ping Shang Louise van der Weyden Kim Wong Oliver Holmes Serigne Lo Conrad Leonard Scott Wood Qinying Xu Robert V. Rawson Pamela Mukhopadhyay Reinhard Dummer Mitchell P. Levesque Göran Jönsson Xuan Wang Iwei Yeh Hong Wu Nancy Joseph Boris C. Bastian Georgina V. Long Andrew J. Spillane Kerwin F. Shannon John F. Thompson Robyn P. M. Saw David J. Adams Lu Si John V. Pearson Nicholas K. Hayward Nicola Waddell Graham J. Mann Jun Guo Richard A. Scolyer |
| author_facet |
Felicity Newell Yan Kong James S. Wilmott Peter A. Johansson Peter M. Ferguson Chuanliang Cui Zhongwu Li Stephen H. Kazakoff Hazel Burke Tristan J. Dodds Ann-Marie Patch Katia Nones Varsha Tembe Ping Shang Louise van der Weyden Kim Wong Oliver Holmes Serigne Lo Conrad Leonard Scott Wood Qinying Xu Robert V. Rawson Pamela Mukhopadhyay Reinhard Dummer Mitchell P. Levesque Göran Jönsson Xuan Wang Iwei Yeh Hong Wu Nancy Joseph Boris C. Bastian Georgina V. Long Andrew J. Spillane Kerwin F. Shannon John F. Thompson Robyn P. M. Saw David J. Adams Lu Si John V. Pearson Nicholas K. Hayward Nicola Waddell Graham J. Mann Jun Guo Richard A. Scolyer |
| author_sort |
Felicity Newell |
| title |
Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets |
| title_short |
Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets |
| title_full |
Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets |
| title_fullStr |
Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets |
| title_full_unstemmed |
Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets |
| title_sort |
whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/2e6c660727314c7ebfed4a9f82ef05a8 |
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