RNA editing derived epitopes function as cancer antigens to elicit immune responses

RNA editing is a biological process that creates sequence variation. Here the authors show that peptides generated as a consequence of RNA editing are naturally presented by human leukocyte antigen (HLA) and serve as antigens to elicit anti-tumour immune responses.

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Autores principales:	Minying Zhang, Jens Fritsche, Jason Roszik, Leila J. Williams, Xinxin Peng, Yulun Chiu, Chih-Chiang Tsou, Franziska Hoffgaard, Valentina Goldfinger, Oliver Schoor, Amjad Talukder, Marie A. Forget, Cara Haymaker, Chantale Bernatchez, Leng Han, Yiu-Huen Tsang, Kathleen Kong, Xiaoyan Xu, Kenneth L. Scott, Harpreet Singh-Jasuja, Greg Lizee, Han Liang, Toni Weinschenk, Gordon B. Mills, Patrick Hwu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2e9bfb402d00408685976df0bcbc9b99
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spelling	oai:doaj.org-article:2e9bfb402d00408685976df0bcbc9b992021-12-02T15:33:46ZRNA editing derived epitopes function as cancer antigens to elicit immune responses10.1038/s41467-018-06405-92041-1723https://doaj.org/article/2e9bfb402d00408685976df0bcbc9b992018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06405-9https://doaj.org/toc/2041-1723RNA editing is a biological process that creates sequence variation. Here the authors show that peptides generated as a consequence of RNA editing are naturally presented by human leukocyte antigen (HLA) and serve as antigens to elicit anti-tumour immune responses.Minying ZhangJens FritscheJason RoszikLeila J. WilliamsXinxin PengYulun ChiuChih-Chiang TsouFranziska HoffgaardValentina GoldfingerOliver SchoorAmjad TalukderMarie A. ForgetCara HaymakerChantale BernatchezLeng HanYiu-Huen TsangKathleen KongXiaoyan XuKenneth L. ScottHarpreet Singh-JasujaGreg LizeeHan LiangToni WeinschenkGordon B. MillsPatrick HwuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minying Zhang Jens Fritsche Jason Roszik Leila J. Williams Xinxin Peng Yulun Chiu Chih-Chiang Tsou Franziska Hoffgaard Valentina Goldfinger Oliver Schoor Amjad Talukder Marie A. Forget Cara Haymaker Chantale Bernatchez Leng Han Yiu-Huen Tsang Kathleen Kong Xiaoyan Xu Kenneth L. Scott Harpreet Singh-Jasuja Greg Lizee Han Liang Toni Weinschenk Gordon B. Mills Patrick Hwu RNA editing derived epitopes function as cancer antigens to elicit immune responses
description	RNA editing is a biological process that creates sequence variation. Here the authors show that peptides generated as a consequence of RNA editing are naturally presented by human leukocyte antigen (HLA) and serve as antigens to elicit anti-tumour immune responses.
format	article
author	Minying Zhang Jens Fritsche Jason Roszik Leila J. Williams Xinxin Peng Yulun Chiu Chih-Chiang Tsou Franziska Hoffgaard Valentina Goldfinger Oliver Schoor Amjad Talukder Marie A. Forget Cara Haymaker Chantale Bernatchez Leng Han Yiu-Huen Tsang Kathleen Kong Xiaoyan Xu Kenneth L. Scott Harpreet Singh-Jasuja Greg Lizee Han Liang Toni Weinschenk Gordon B. Mills Patrick Hwu
author_facet	Minying Zhang Jens Fritsche Jason Roszik Leila J. Williams Xinxin Peng Yulun Chiu Chih-Chiang Tsou Franziska Hoffgaard Valentina Goldfinger Oliver Schoor Amjad Talukder Marie A. Forget Cara Haymaker Chantale Bernatchez Leng Han Yiu-Huen Tsang Kathleen Kong Xiaoyan Xu Kenneth L. Scott Harpreet Singh-Jasuja Greg Lizee Han Liang Toni Weinschenk Gordon B. Mills Patrick Hwu
author_sort	Minying Zhang
title	RNA editing derived epitopes function as cancer antigens to elicit immune responses
title_short	RNA editing derived epitopes function as cancer antigens to elicit immune responses
title_full	RNA editing derived epitopes function as cancer antigens to elicit immune responses
title_fullStr	RNA editing derived epitopes function as cancer antigens to elicit immune responses
title_full_unstemmed	RNA editing derived epitopes function as cancer antigens to elicit immune responses
title_sort	rna editing derived epitopes function as cancer antigens to elicit immune responses
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2e9bfb402d00408685976df0bcbc9b99
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RNA editing derived epitopes function as cancer antigens to elicit immune responses

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