Bioactive’s Characterization, Biological Activities, and In Silico Studies of Red Onion (<i>Allium cepa</i> L.) Skin Extracts

This study aimed to investigate the thermal stability and biological activities of the phytochemicals from the red onion skins extract, which are a rich source of anthocyanins. Eight anthocyanins were identified in the extract by high-performance liquid chromatography, the most abundant ones being c...

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Autores principales:	Florina Stoica, Iuliana Aprodu, Elena Enachi, Nicoleta Stănciuc, Nina Nicoleta Condurache, Denisa Eglantina Duță, Gabriela Elena Bahrim, Gabriela Râpeanu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	red onion skins anthocyanins antioxidant activity thermal stability molecular modeling biological activity Botany QK1-989
Acceso en línea:	https://doaj.org/article/2ec08d5676a047c6bac7971b6c9655dd
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spelling	oai:doaj.org-article:2ec08d5676a047c6bac7971b6c9655dd2021-11-25T18:45:24ZBioactive’s Characterization, Biological Activities, and In Silico Studies of Red Onion (<i>Allium cepa</i> L.) Skin Extracts10.3390/plants101123302223-7747https://doaj.org/article/2ec08d5676a047c6bac7971b6c9655dd2021-10-01T00:00:00Zhttps://www.mdpi.com/2223-7747/10/11/2330https://doaj.org/toc/2223-7747This study aimed to investigate the thermal stability and biological activities of the phytochemicals from the red onion skins extract, which are a rich source of anthocyanins. Eight anthocyanins were identified in the extract by high-performance liquid chromatography, the most abundant ones being cyanidin 3-<i>O</i>-laminaribioside and cyanidin 3-<i>O</i>-(6″-malonoyl-laminaribioside). The study also involved the assessment of the thermal degradation kinetics of anthocyanins and antioxidant activity in the 75–155 °C temperature range. The thermal degradation kinetics was described using the first-order kinetics model. In terms of thermal stability, increasing the temperature resulted in lower half-life values (t<sub>1/2</sub>) and higher degradation rate constant values (k) for both anthocyanins and antioxidant activity. The thermodynamic parameters revealed that the phytochemicals’ degradation is a non-spontaneous and endothermic reaction. Furthermore, the inhibitory effect of the extract was investigated against the enzymes affiliated with metabolic syndrome, oxidative stress, and inflammatory process diseases. Thus, we also demonstrated that the red onion skins extract exerted inhibitory activity on α-glucosidase, α-amylase, lipase, and lipoxygenase. Considering the high content of bioactives and various biological properties, the red onion skins extract is suitable for multiple applications.Florina StoicaIuliana AproduElena EnachiNicoleta StănciucNina Nicoleta ConduracheDenisa Eglantina DuțăGabriela Elena BahrimGabriela RâpeanuMDPI AGarticlered onion skinsanthocyaninsantioxidant activitythermal stabilitymolecular modelingbiological activityBotanyQK1-989ENPlants, Vol 10, Iss 2330, p 2330 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	red onion skins anthocyanins antioxidant activity thermal stability molecular modeling biological activity Botany QK1-989
spellingShingle	red onion skins anthocyanins antioxidant activity thermal stability molecular modeling biological activity Botany QK1-989 Florina Stoica Iuliana Aprodu Elena Enachi Nicoleta Stănciuc Nina Nicoleta Condurache Denisa Eglantina Duță Gabriela Elena Bahrim Gabriela Râpeanu Bioactive’s Characterization, Biological Activities, and In Silico Studies of Red Onion (<i>Allium cepa</i> L.) Skin Extracts
description	This study aimed to investigate the thermal stability and biological activities of the phytochemicals from the red onion skins extract, which are a rich source of anthocyanins. Eight anthocyanins were identified in the extract by high-performance liquid chromatography, the most abundant ones being cyanidin 3-<i>O</i>-laminaribioside and cyanidin 3-<i>O</i>-(6″-malonoyl-laminaribioside). The study also involved the assessment of the thermal degradation kinetics of anthocyanins and antioxidant activity in the 75–155 °C temperature range. The thermal degradation kinetics was described using the first-order kinetics model. In terms of thermal stability, increasing the temperature resulted in lower half-life values (t<sub>1/2</sub>) and higher degradation rate constant values (k) for both anthocyanins and antioxidant activity. The thermodynamic parameters revealed that the phytochemicals’ degradation is a non-spontaneous and endothermic reaction. Furthermore, the inhibitory effect of the extract was investigated against the enzymes affiliated with metabolic syndrome, oxidative stress, and inflammatory process diseases. Thus, we also demonstrated that the red onion skins extract exerted inhibitory activity on α-glucosidase, α-amylase, lipase, and lipoxygenase. Considering the high content of bioactives and various biological properties, the red onion skins extract is suitable for multiple applications.
format	article
author	Florina Stoica Iuliana Aprodu Elena Enachi Nicoleta Stănciuc Nina Nicoleta Condurache Denisa Eglantina Duță Gabriela Elena Bahrim Gabriela Râpeanu
author_facet	Florina Stoica Iuliana Aprodu Elena Enachi Nicoleta Stănciuc Nina Nicoleta Condurache Denisa Eglantina Duță Gabriela Elena Bahrim Gabriela Râpeanu
author_sort	Florina Stoica
title	Bioactive’s Characterization, Biological Activities, and In Silico Studies of Red Onion (<i>Allium cepa</i> L.) Skin Extracts
title_short	Bioactive’s Characterization, Biological Activities, and In Silico Studies of Red Onion (<i>Allium cepa</i> L.) Skin Extracts
title_full	Bioactive’s Characterization, Biological Activities, and In Silico Studies of Red Onion (<i>Allium cepa</i> L.) Skin Extracts
title_fullStr	Bioactive’s Characterization, Biological Activities, and In Silico Studies of Red Onion (<i>Allium cepa</i> L.) Skin Extracts
title_full_unstemmed	Bioactive’s Characterization, Biological Activities, and In Silico Studies of Red Onion (<i>Allium cepa</i> L.) Skin Extracts
title_sort	bioactive’s characterization, biological activities, and in silico studies of red onion (<i>allium cepa</i> l.) skin extracts
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2ec08d5676a047c6bac7971b6c9655dd
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Bioactive’s Characterization, Biological Activities, and In Silico Studies of Red Onion (<i>Allium cepa</i> L.) Skin Extracts

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