Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice

Abstract Chromosomal instability (CIN) is a hallmark of cancer, leading to aneuploid cells. To study the role that CIN plays in tumor evolution, several mouse models have been engineered over the last 2 decades. These models have unequivocally shown that systemic high-grade CIN is embryonic lethal....

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Autores principales: Klaske M. Schukken, Yinan Zhu, Petra L. Bakker, Mirjam H. Koster, Liesbeth Harkema, Sameh A. Youssef, Alain de Bruin, Floris Foijer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2ee0cafcaa344471b97c2a117ffcebdc
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