The effects of mutational processes and selection on driver mutations across cancer types

A central question in cancer research is how specific driver mutations are acquired and maintained during cancer development. Here Temko et al. use public sequencing data to infer the effect of mutation and selection on a set of driver mutations and suggest that selection frequently dominates.

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Autores principales: Daniel Temko, Ian P. M. Tomlinson, Simone Severini, Benjamin Schuster-Böckler, Trevor A. Graham
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/2f20429856604bb1a50d0d6d22d58faa
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