The effects of mutational processes and selection on driver mutations across cancer types

A central question in cancer research is how specific driver mutations are acquired and maintained during cancer development. Here Temko et al. use public sequencing data to infer the effect of mutation and selection on a set of driver mutations and suggest that selection frequently dominates.

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Autores principales:	Daniel Temko, Ian P. M. Tomlinson, Simone Severini, Benjamin Schuster-Böckler, Trevor A. Graham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f20429856604bb1a50d0d6d22d58faa
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spelling	oai:doaj.org-article:2f20429856604bb1a50d0d6d22d58faa2021-12-02T15:34:24ZThe effects of mutational processes and selection on driver mutations across cancer types10.1038/s41467-018-04208-62041-1723https://doaj.org/article/2f20429856604bb1a50d0d6d22d58faa2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04208-6https://doaj.org/toc/2041-1723A central question in cancer research is how specific driver mutations are acquired and maintained during cancer development. Here Temko et al. use public sequencing data to infer the effect of mutation and selection on a set of driver mutations and suggest that selection frequently dominates.Daniel TemkoIan P. M. TomlinsonSimone SeveriniBenjamin Schuster-BöcklerTrevor A. GrahamNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Temko Ian P. M. Tomlinson Simone Severini Benjamin Schuster-Böckler Trevor A. Graham The effects of mutational processes and selection on driver mutations across cancer types
description	A central question in cancer research is how specific driver mutations are acquired and maintained during cancer development. Here Temko et al. use public sequencing data to infer the effect of mutation and selection on a set of driver mutations and suggest that selection frequently dominates.
format	article
author	Daniel Temko Ian P. M. Tomlinson Simone Severini Benjamin Schuster-Böckler Trevor A. Graham
author_facet	Daniel Temko Ian P. M. Tomlinson Simone Severini Benjamin Schuster-Böckler Trevor A. Graham
author_sort	Daniel Temko
title	The effects of mutational processes and selection on driver mutations across cancer types
title_short	The effects of mutational processes and selection on driver mutations across cancer types
title_full	The effects of mutational processes and selection on driver mutations across cancer types
title_fullStr	The effects of mutational processes and selection on driver mutations across cancer types
title_full_unstemmed	The effects of mutational processes and selection on driver mutations across cancer types
title_sort	effects of mutational processes and selection on driver mutations across cancer types
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2f20429856604bb1a50d0d6d22d58faa
work_keys_str_mv	AT danieltemko theeffectsofmutationalprocessesandselectionondrivermutationsacrosscancertypes AT ianpmtomlinson theeffectsofmutationalprocessesandselectionondrivermutationsacrosscancertypes AT simoneseverini theeffectsofmutationalprocessesandselectionondrivermutationsacrosscancertypes AT benjaminschusterbockler theeffectsofmutationalprocessesandselectionondrivermutationsacrosscancertypes AT trevoragraham theeffectsofmutationalprocessesandselectionondrivermutationsacrosscancertypes AT danieltemko effectsofmutationalprocessesandselectionondrivermutationsacrosscancertypes AT ianpmtomlinson effectsofmutationalprocessesandselectionondrivermutationsacrosscancertypes AT simoneseverini effectsofmutationalprocessesandselectionondrivermutationsacrosscancertypes AT benjaminschusterbockler effectsofmutationalprocessesandselectionondrivermutationsacrosscancertypes AT trevoragraham effectsofmutationalprocessesandselectionondrivermutationsacrosscancertypes
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The effects of mutational processes and selection on driver mutations across cancer types

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