Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.

Kaposi sarcoma is a tumor consisting of Kaposi sarcoma herpesvirus (KSHV)-infected tumor cells that express endothelial cell (EC) markers and viral genes like v-cyclin, vFLIP, and LANA. Despite a strong link between KSHV infection and certain neoplasms, de novo virus infection of human primary cells...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sonja Koopal, Johanna H Furuhjelm, Annika Järviluoma, Sari Jäämaa, Pawan Pyakurel, Christel Pussinen, Maria Wirzenius, Peter Biberfeld, Kari Alitalo, Marikki Laiho, Päivi M Ojala
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2007
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2f23eda7c9764a07baabb81a431641b6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2f23eda7c9764a07baabb81a431641b6
record_format	dspace
spelling	oai:doaj.org-article:2f23eda7c9764a07baabb81a431641b62021-11-25T05:46:23ZViral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.1553-73661553-737410.1371/journal.ppat.0030140https://doaj.org/article/2f23eda7c9764a07baabb81a431641b62007-09-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.0030140https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Kaposi sarcoma is a tumor consisting of Kaposi sarcoma herpesvirus (KSHV)-infected tumor cells that express endothelial cell (EC) markers and viral genes like v-cyclin, vFLIP, and LANA. Despite a strong link between KSHV infection and certain neoplasms, de novo virus infection of human primary cells does not readily lead to cellular transformation. We have studied the consequences of expression of v-cyclin in primary and immortalized human dermal microvascular ECs. We show that v-cyclin, which is a homolog of cellular D-type cyclins, induces replicative stress in ECs, which leads to senescence and activation of the DNA damage response. We find that antiproliferative checkpoints are activated upon KSHV infection of ECs, and in early-stage but not late-stage lesions of clinical Kaposi sarcoma specimens. These are some of the first results suggesting that DNA damage checkpoint response also functions as an anticancer barrier in virally induced cancers.Sonja KoopalJohanna H FuruhjelmAnnika JärviluomaSari JäämaaPawan PyakurelChristel PussinenMaria WirzeniusPeter BiberfeldKari AlitaloMarikki LaihoPäivi M OjalaPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 3, Iss 9, Pp 1348-1360 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Sonja Koopal Johanna H Furuhjelm Annika Järviluoma Sari Jäämaa Pawan Pyakurel Christel Pussinen Maria Wirzenius Peter Biberfeld Kari Alitalo Marikki Laiho Päivi M Ojala Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.
description	Kaposi sarcoma is a tumor consisting of Kaposi sarcoma herpesvirus (KSHV)-infected tumor cells that express endothelial cell (EC) markers and viral genes like v-cyclin, vFLIP, and LANA. Despite a strong link between KSHV infection and certain neoplasms, de novo virus infection of human primary cells does not readily lead to cellular transformation. We have studied the consequences of expression of v-cyclin in primary and immortalized human dermal microvascular ECs. We show that v-cyclin, which is a homolog of cellular D-type cyclins, induces replicative stress in ECs, which leads to senescence and activation of the DNA damage response. We find that antiproliferative checkpoints are activated upon KSHV infection of ECs, and in early-stage but not late-stage lesions of clinical Kaposi sarcoma specimens. These are some of the first results suggesting that DNA damage checkpoint response also functions as an anticancer barrier in virally induced cancers.
format	article
author	Sonja Koopal Johanna H Furuhjelm Annika Järviluoma Sari Jäämaa Pawan Pyakurel Christel Pussinen Maria Wirzenius Peter Biberfeld Kari Alitalo Marikki Laiho Päivi M Ojala
author_facet	Sonja Koopal Johanna H Furuhjelm Annika Järviluoma Sari Jäämaa Pawan Pyakurel Christel Pussinen Maria Wirzenius Peter Biberfeld Kari Alitalo Marikki Laiho Päivi M Ojala
author_sort	Sonja Koopal
title	Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.
title_short	Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.
title_full	Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.
title_fullStr	Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.
title_full_unstemmed	Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.
title_sort	viral oncogene-induced dna damage response is activated in kaposi sarcoma tumorigenesis.
publisher	Public Library of Science (PLoS)
publishDate	2007
url	https://doaj.org/article/2f23eda7c9764a07baabb81a431641b6
work_keys_str_mv	AT sonjakoopal viraloncogeneinduceddnadamageresponseisactivatedinkaposisarcomatumorigenesis AT johannahfuruhjelm viraloncogeneinduceddnadamageresponseisactivatedinkaposisarcomatumorigenesis AT annikajarviluoma viraloncogeneinduceddnadamageresponseisactivatedinkaposisarcomatumorigenesis AT sarijaamaa viraloncogeneinduceddnadamageresponseisactivatedinkaposisarcomatumorigenesis AT pawanpyakurel viraloncogeneinduceddnadamageresponseisactivatedinkaposisarcomatumorigenesis AT christelpussinen viraloncogeneinduceddnadamageresponseisactivatedinkaposisarcomatumorigenesis AT mariawirzenius viraloncogeneinduceddnadamageresponseisactivatedinkaposisarcomatumorigenesis AT peterbiberfeld viraloncogeneinduceddnadamageresponseisactivatedinkaposisarcomatumorigenesis AT karialitalo viraloncogeneinduceddnadamageresponseisactivatedinkaposisarcomatumorigenesis AT marikkilaiho viraloncogeneinduceddnadamageresponseisactivatedinkaposisarcomatumorigenesis AT paivimojala viraloncogeneinduceddnadamageresponseisactivatedinkaposisarcomatumorigenesis
_version_	1718414449954521088

Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.

Ejemplares similares