Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

Mucosal-associated invariant T (MAIT) cells sense riboflavin biosynthetic intermediate antigens with a semi-invariant MR1-restricted T-cell receptor (TCR). Here the authors identify a new MR1-restricted TCR that senses cells infected with S. pyogenes, a bacteria unable to biosynthesize riboflavin.

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Auteurs principaux:	Erin W. Meermeier, Bruno F. Laugel, Andrew K. Sewell, Alexandra J. Corbett, Jamie Rossjohn, James McCluskey, Melanie J. Harriff, Tamera Franks, Marielle C. Gold, David M. Lewinsohn
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/2f24c468add3498dadcef365ff8b0219
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spelling	oai:doaj.org-article:2f24c468add3498dadcef365ff8b02192021-12-02T16:49:26ZHuman TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens10.1038/ncomms125062041-1723https://doaj.org/article/2f24c468add3498dadcef365ff8b02192016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12506https://doaj.org/toc/2041-1723Mucosal-associated invariant T (MAIT) cells sense riboflavin biosynthetic intermediate antigens with a semi-invariant MR1-restricted T-cell receptor (TCR). Here the authors identify a new MR1-restricted TCR that senses cells infected with S. pyogenes, a bacteria unable to biosynthesize riboflavin.Erin W. MeermeierBruno F. LaugelAndrew K. SewellAlexandra J. CorbettJamie RossjohnJames McCluskeyMelanie J. HarriffTamera FranksMarielle C. GoldDavid M. LewinsohnNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erin W. Meermeier Bruno F. Laugel Andrew K. Sewell Alexandra J. Corbett Jamie Rossjohn James McCluskey Melanie J. Harriff Tamera Franks Marielle C. Gold David M. Lewinsohn Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens
description	Mucosal-associated invariant T (MAIT) cells sense riboflavin biosynthetic intermediate antigens with a semi-invariant MR1-restricted T-cell receptor (TCR). Here the authors identify a new MR1-restricted TCR that senses cells infected with S. pyogenes, a bacteria unable to biosynthesize riboflavin.
format	article
author	Erin W. Meermeier Bruno F. Laugel Andrew K. Sewell Alexandra J. Corbett Jamie Rossjohn James McCluskey Melanie J. Harriff Tamera Franks Marielle C. Gold David M. Lewinsohn
author_facet	Erin W. Meermeier Bruno F. Laugel Andrew K. Sewell Alexandra J. Corbett Jamie Rossjohn James McCluskey Melanie J. Harriff Tamera Franks Marielle C. Gold David M. Lewinsohn
author_sort	Erin W. Meermeier
title	Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens
title_short	Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens
title_full	Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens
title_fullStr	Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens
title_full_unstemmed	Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens
title_sort	human trav1-2-negative mr1-restricted t cells detect s. pyogenes and alternatives to mait riboflavin-based antigens
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2f24c468add3498dadcef365ff8b0219
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Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

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