A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry

A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry

Zika virus (ZIKV) is a re-emerging flavivirus that has caused large-scale epidemics. Infection during pregnancy can lead to neurologic developmental abnormalities in children. There is no approved vaccine or therapy for ZIKV. To uncover cellular pathways required for ZIKV that can be therapeutically...

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Autores principales: Anh Phuong Luu, Zhenlan Yao, Sangeetha Ramachandran, Stephanie A. Azzopardi, Linde A. Miles, William M. Schneider, H.-Heinrich Hoffmann, Leonia Bozzacco, Gustavo Garcia, Danyang Gong, Robert Damoiseaux, Hengli Tang, Kouki Morizono, Charles M. Rudin, Ren Sun, Vaithilingaraja Arumugaswami, John T. Poirier, Margaret R. MacDonald, Charles M. Rice, Melody M. H. Li
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
CRISPR activation
Zika virus
proviral factors
WWTR1
Rho GTPases
RhoV
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/2f3d203580654a47b1222b3bf06f5e6f
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https://doaj.org/article/2f3d203580654a47b1222b3bf06f5e6f

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