Identification and structural analysis of the tripartite α-pore forming toxin of Aeromonas hydrophila

Pore forming toxins (PFTs) form the major group of virulence factors in many pathogenic bacteria. Here the authors identify tripartite α-helical PFTs in pathogenic Gram negative bacteria and structurally characterize AhlABC from Aeromonas hydrophila and propose a model for its pore assembly.

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Autores principales:	Jason S. Wilson, Alicia M. Churchill-Angus, Simon P. Davies, Svetlana E. Sedelnikova, Svetomir B. Tzokov, John B. Rafferty, Per A. Bullough, Claudine Bisson, Patrick J. Baker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f6b67a180744391895b4f4a9d6daa29
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spelling	oai:doaj.org-article:2f6b67a180744391895b4f4a9d6daa292021-12-02T15:35:53ZIdentification and structural analysis of the tripartite α-pore forming toxin of Aeromonas hydrophila10.1038/s41467-019-10777-x2041-1723https://doaj.org/article/2f6b67a180744391895b4f4a9d6daa292019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10777-xhttps://doaj.org/toc/2041-1723Pore forming toxins (PFTs) form the major group of virulence factors in many pathogenic bacteria. Here the authors identify tripartite α-helical PFTs in pathogenic Gram negative bacteria and structurally characterize AhlABC from Aeromonas hydrophila and propose a model for its pore assembly.Jason S. WilsonAlicia M. Churchill-AngusSimon P. DaviesSvetlana E. SedelnikovaSvetomir B. TzokovJohn B. RaffertyPer A. BulloughClaudine BissonPatrick J. BakerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason S. Wilson Alicia M. Churchill-Angus Simon P. Davies Svetlana E. Sedelnikova Svetomir B. Tzokov John B. Rafferty Per A. Bullough Claudine Bisson Patrick J. Baker Identification and structural analysis of the tripartite α-pore forming toxin of Aeromonas hydrophila
description	Pore forming toxins (PFTs) form the major group of virulence factors in many pathogenic bacteria. Here the authors identify tripartite α-helical PFTs in pathogenic Gram negative bacteria and structurally characterize AhlABC from Aeromonas hydrophila and propose a model for its pore assembly.
format	article
author	Jason S. Wilson Alicia M. Churchill-Angus Simon P. Davies Svetlana E. Sedelnikova Svetomir B. Tzokov John B. Rafferty Per A. Bullough Claudine Bisson Patrick J. Baker
author_facet	Jason S. Wilson Alicia M. Churchill-Angus Simon P. Davies Svetlana E. Sedelnikova Svetomir B. Tzokov John B. Rafferty Per A. Bullough Claudine Bisson Patrick J. Baker
author_sort	Jason S. Wilson
title	Identification and structural analysis of the tripartite α-pore forming toxin of Aeromonas hydrophila
title_short	Identification and structural analysis of the tripartite α-pore forming toxin of Aeromonas hydrophila
title_full	Identification and structural analysis of the tripartite α-pore forming toxin of Aeromonas hydrophila
title_fullStr	Identification and structural analysis of the tripartite α-pore forming toxin of Aeromonas hydrophila
title_full_unstemmed	Identification and structural analysis of the tripartite α-pore forming toxin of Aeromonas hydrophila
title_sort	identification and structural analysis of the tripartite α-pore forming toxin of aeromonas hydrophila
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2f6b67a180744391895b4f4a9d6daa29
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Identification and structural analysis of the tripartite α-pore forming toxin of Aeromonas hydrophila

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