Non-canonical NOTCH3 signalling limits tumour angiogenesis

Notch signalling is deregulated in several cancers; therefore, strategies targeting this pathway are currently being explored. Here the authors report a pro-apoptotic function of Notch3 in endothelial cells; consequently, when Notch3 is silenced in stroma cells, tumour growth and angiogenesis are in...

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Bibliographic Details
Main Authors: Shuheng Lin, Ana Negulescu, Sirisha Bulusu, Benjamin Gibert, Jean-Guy Delcros, Benjamin Ducarouge, Nicolas Rama, Nicolas Gadot, Isabelle Treilleux, Pierre Saintigny, Olivier Meurette, Patrick Mehlen
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/2f70525d7341492bb8bcac42457a17af
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