Non-canonical NOTCH3 signalling limits tumour angiogenesis

Notch signalling is deregulated in several cancers; therefore, strategies targeting this pathway are currently being explored. Here the authors report a pro-apoptotic function of Notch3 in endothelial cells; consequently, when Notch3 is silenced in stroma cells, tumour growth and angiogenesis are in...

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Autores principales:	Shuheng Lin, Ana Negulescu, Sirisha Bulusu, Benjamin Gibert, Jean-Guy Delcros, Benjamin Ducarouge, Nicolas Rama, Nicolas Gadot, Isabelle Treilleux, Pierre Saintigny, Olivier Meurette, Patrick Mehlen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f70525d7341492bb8bcac42457a17af
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spelling	oai:doaj.org-article:2f70525d7341492bb8bcac42457a17af2021-12-02T17:06:22ZNon-canonical NOTCH3 signalling limits tumour angiogenesis10.1038/ncomms160742041-1723https://doaj.org/article/2f70525d7341492bb8bcac42457a17af2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16074https://doaj.org/toc/2041-1723Notch signalling is deregulated in several cancers; therefore, strategies targeting this pathway are currently being explored. Here the authors report a pro-apoptotic function of Notch3 in endothelial cells; consequently, when Notch3 is silenced in stroma cells, tumour growth and angiogenesis are increased.Shuheng LinAna NegulescuSirisha BulusuBenjamin GibertJean-Guy DelcrosBenjamin DucarougeNicolas RamaNicolas GadotIsabelle TreilleuxPierre SaintignyOlivier MeurettePatrick MehlenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuheng Lin Ana Negulescu Sirisha Bulusu Benjamin Gibert Jean-Guy Delcros Benjamin Ducarouge Nicolas Rama Nicolas Gadot Isabelle Treilleux Pierre Saintigny Olivier Meurette Patrick Mehlen Non-canonical NOTCH3 signalling limits tumour angiogenesis
description	Notch signalling is deregulated in several cancers; therefore, strategies targeting this pathway are currently being explored. Here the authors report a pro-apoptotic function of Notch3 in endothelial cells; consequently, when Notch3 is silenced in stroma cells, tumour growth and angiogenesis are increased.
format	article
author	Shuheng Lin Ana Negulescu Sirisha Bulusu Benjamin Gibert Jean-Guy Delcros Benjamin Ducarouge Nicolas Rama Nicolas Gadot Isabelle Treilleux Pierre Saintigny Olivier Meurette Patrick Mehlen
author_facet	Shuheng Lin Ana Negulescu Sirisha Bulusu Benjamin Gibert Jean-Guy Delcros Benjamin Ducarouge Nicolas Rama Nicolas Gadot Isabelle Treilleux Pierre Saintigny Olivier Meurette Patrick Mehlen
author_sort	Shuheng Lin
title	Non-canonical NOTCH3 signalling limits tumour angiogenesis
title_short	Non-canonical NOTCH3 signalling limits tumour angiogenesis
title_full	Non-canonical NOTCH3 signalling limits tumour angiogenesis
title_fullStr	Non-canonical NOTCH3 signalling limits tumour angiogenesis
title_full_unstemmed	Non-canonical NOTCH3 signalling limits tumour angiogenesis
title_sort	non-canonical notch3 signalling limits tumour angiogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2f70525d7341492bb8bcac42457a17af
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Non-canonical NOTCH3 signalling limits tumour angiogenesis

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