Drug Repositioning Based on the Reversal of Gene Expression Signatures Identifies <i>TOP2A</i> as a Therapeutic Target for Rectal Cancer

Drug Repositioning Based on the Reversal of Gene Expression Signatures Identifies <i>TOP2A</i> as a Therapeutic Target for Rectal Cancer

Rectal cancer is a common disease with high mortality rates and limited therapeutic options. Here we combined the gene expression signatures of rectal cancer patients with the reverse drug-induced gene-expression profiles to identify drug repositioning candidates for cancer therapy. Among the predic...

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Bibliographic Details
Main Authors: Robson Francisco Carvalho, Luisa Matos do Canto, Sarah Santiloni Cury, Torben Frøstrup Hansen, Lars Henrik Jensen, Silvia Regina Rogatto
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
rectal cancer
drug repositioning
reverse expression of signature genes
gene expression features
drug reversal potency scoring
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/2f8dc78127b245109a3a9f766d7f5edc
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https://doaj.org/article/2f8dc78127b245109a3a9f766d7f5edc

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