Functional and computational identification of a rescue mutation near the active site of an mRNA methyltransferase

Abstract RNA-based drugs are an emerging class of therapeutics combining the immense potential of DNA gene-therapy with the absence of genome integration-associated risks. While the synthesis of such molecules is feasible, large scale in vitro production of humanised mRNA remains a biochemical and e...

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Bibliographic Details
Main Authors: Pierre-Yves Colin, Paul A. Dalby
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
R
Q
Online Access:https://doaj.org/article/2f9517bf037f477d8cdc334243cc1253
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