DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells

T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2) respond differently to interleukin-33 (IL-33) stimulation. Here the authors show that a phosphatase, Dusp10, is expressed in Th2, but not ILC2, to dephosphorylate p38 kinase, reduce GATA3 transcription factor activity, and suppress the i...

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Autores principales:	Takeshi Yamamoto, Yusuke Endo, Atsushi Onodera, Kiyoshi Hirahara, Hikari K. Asou, Takahiro Nakajima, Toshio Kanno, Yasuo Ouchi, Satoshi Uematsu, Hiroshi Nishimasu, Osamu Nureki, Damon J. Tumes, Naoki Shimojo, Toshinori Nakayama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2fa4e1b6bbf74a90bf17ce9936a84fec
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spelling	oai:doaj.org-article:2fa4e1b6bbf74a90bf17ce9936a84fec2021-12-02T15:34:44ZDUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells10.1038/s41467-018-06468-82041-1723https://doaj.org/article/2fa4e1b6bbf74a90bf17ce9936a84fec2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06468-8https://doaj.org/toc/2041-1723T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2) respond differently to interleukin-33 (IL-33) stimulation. Here the authors show that a phosphatase, Dusp10, is expressed in Th2, but not ILC2, to dephosphorylate p38 kinase, reduce GATA3 transcription factor activity, and suppress the induction of IL-5 in response to IL-33.Takeshi YamamotoYusuke EndoAtsushi OnoderaKiyoshi HiraharaHikari K. AsouTakahiro NakajimaToshio KannoYasuo OuchiSatoshi UematsuHiroshi NishimasuOsamu NurekiDamon J. TumesNaoki ShimojoToshinori NakayamaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takeshi Yamamoto Yusuke Endo Atsushi Onodera Kiyoshi Hirahara Hikari K. Asou Takahiro Nakajima Toshio Kanno Yasuo Ouchi Satoshi Uematsu Hiroshi Nishimasu Osamu Nureki Damon J. Tumes Naoki Shimojo Toshinori Nakayama DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells
description	T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2) respond differently to interleukin-33 (IL-33) stimulation. Here the authors show that a phosphatase, Dusp10, is expressed in Th2, but not ILC2, to dephosphorylate p38 kinase, reduce GATA3 transcription factor activity, and suppress the induction of IL-5 in response to IL-33.
format	article
author	Takeshi Yamamoto Yusuke Endo Atsushi Onodera Kiyoshi Hirahara Hikari K. Asou Takahiro Nakajima Toshio Kanno Yasuo Ouchi Satoshi Uematsu Hiroshi Nishimasu Osamu Nureki Damon J. Tumes Naoki Shimojo Toshinori Nakayama
author_facet	Takeshi Yamamoto Yusuke Endo Atsushi Onodera Kiyoshi Hirahara Hikari K. Asou Takahiro Nakajima Toshio Kanno Yasuo Ouchi Satoshi Uematsu Hiroshi Nishimasu Osamu Nureki Damon J. Tumes Naoki Shimojo Toshinori Nakayama
author_sort	Takeshi Yamamoto
title	DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells
title_short	DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells
title_full	DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells
title_fullStr	DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells
title_full_unstemmed	DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells
title_sort	dusp10 constrains innate il-33-mediated cytokine production in st2hi memory-type pathogenic th2 cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2fa4e1b6bbf74a90bf17ce9936a84fec
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DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells

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