Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy

por Mikihiro Shibata, Hiroshi Nishimasu, Noriyuki Kodera, Seiichi Hirano, Toshio Ando, Takayuki Uchihashi, Osamu Nureki
Publicado 2017

Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG

por Seiya Oura, Taichi Noda, Naoko Morimura, Seiji Hitoshi, Hiroshi Nishimasu, Yoshitaka Nagai, Osamu Nureki, Masahito Ikawa
Publicado 2021

Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide

por Junko Morita, Kazuki Kato, Takanori Nakane, Yuki Kondo, Hiroo Fukuda, Hiroshi Nishimasu, Ryuichiro Ishitani, Osamu Nureki
Publicado 2016

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1

por Kazuki Kato, Hiroshi Nishimasu, Daisuke Oikawa, Seiichi Hirano, Hisato Hirano, Go Kasuya, Ryuichiro Ishitani, Fuminori Tokunaga, Osamu Nureki
Publicado 2018

Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9

por Seiichi Hirano, Omar O. Abudayyeh, Jonathan S. Gootenberg, Takuro Horii, Ryuichiro Ishitani, Izuho Hatada, Feng Zhang, Hiroshi Nishimasu, Osamu Nureki
Publicado 2019

Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation

por Wataru Shihoya, Tamaki Izume, Asuka Inoue, Keitaro Yamashita, Francois Marie Ngako Kadji, Kunio Hirata, Junken Aoki, Tomohiro Nishizawa, Osamu Nureki
Publicado 2018

Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

por Kazuki Kato, Yuhkoh Satouh, Hiroshi Nishimasu, Arisa Kurabayashi, Junko Morita, Yoshitaka Fujihara, Asami Oji, Ryuichiro Ishitani, Masahito Ikawa, Osamu Nureki
Publicado 2016

Crystal structure of the red light-activated channelrhodopsin Chrimson

por Kazumasa Oda, Johannes Vierock, Satomi Oishi, Silvia Rodriguez-Rozada, Reiya Taniguchi, Keitaro Yamashita, J. Simon Wiegert, Tomohiro Nishizawa, Peter Hegemann, Osamu Nureki
Publicado 2018

CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice

por Tsukasa Ohmori, Yasumitsu Nagao, Hiroaki Mizukami, Asuka Sakata, Shin-ichi Muramatsu, Keiya Ozawa, Shin-ichi Tominaga, Yutaka Hanazono, Satoshi Nishimura, Osamu Nureki, Yoichi Sakata
Publicado 2017

Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2

por Ko Sato, Amarjeet Kumar, Keisuke Hamada, Chikako Okada, Asako Oguni, Ayumi Machiyama, Shun Sakuraba, Tomohiro Nishizawa, Osamu Nureki, Hidetoshi Kono, Kazuhiro Ogata, Toru Sengoku
Publicado 2021

Structural insights into the mechanism of rhodopsin phosphodiesterase

por Tatsuya Ikuta, Wataru Shihoya, Masahiro Sugiura, Kazuho Yoshida, Masahito Watari, Takaya Tokano, Keitaro Yamashita, Kota Katayama, Satoshi P. Tsunoda, Takayuki Uchihashi, Hideki Kandori, Osamu Nureki
Publicado 2020

Structural insights into tetraspanin CD9 function

por Rie Umeda, Yuhkoh Satouh, Mizuki Takemoto, Yoshiko Nakada-Nakura, Kehong Liu, Takeshi Yokoyama, Mikako Shirouzu, So Iwata, Norimichi Nomura, Ken Sato, Masahito Ikawa, Tomohiro Nishizawa, Osamu Nureki
Publicado 2020

Amplification-free RNA detection with CRISPR–Cas13

por Hajime Shinoda, Yuya Taguchi, Ryoya Nakagawa, Asami Makino, Sae Okazaki, Masahiro Nakano, Yukiko Muramoto, Chiharu Takahashi, Ikuko Takahashi, Jun Ando, Takeshi Noda, Osamu Nureki, Hiroshi Nishimasu, Rikiya Watanabe
Publicado 2021

Structural basis for xenobiotic extrusion by eukaryotic MATE transporter

por Hirotake Miyauchi, Satomi Moriyama, Tsukasa Kusakizako, Kaoru Kumazaki, Takanori Nakane, Keitaro Yamashita, Kunio Hirata, Naoshi Dohmae, Tomohiro Nishizawa, Koichi Ito, Takaaki Miyaji, Yoshinori Moriyama, Ryuichiro Ishitani, Osamu Nureki
Publicado 2017

Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel

por Go Kasuya, Toshiaki Yamaura, Xiao-Bo Ma, Ryoki Nakamura, Mizuki Takemoto, Hiromitsu Nagumo, Eiichi Tanaka, Naoshi Dohmae, Takanori Nakane, Ye Yu, Ryuichiro Ishitani, Osamu Matsuzaki, Motoyuki Hattori, Osamu Nureki
Publicado 2017

Crystal structure of Drosophila Piwi

por Sonomi Yamaguchi, Akira Oe, Kazumichi M. Nishida, Keitaro Yamashita, Asako Kajiya, Seiichi Hirano, Naoki Matsumoto, Naoshi Dohmae, Ryuichiro Ishitani, Kuniaki Saito, Haruhiko Siomi, Hiroshi Nishimasu, Mikiko C. Siomi, Osamu Nureki
Publicado 2020

DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells

por Takeshi Yamamoto, Yusuke Endo, Atsushi Onodera, Kiyoshi Hirahara, Hikari K. Asou, Takahiro Nakajima, Toshio Kanno, Yasuo Ouchi, Satoshi Uematsu, Hiroshi Nishimasu, Osamu Nureki, Damon J. Tumes, Naoki Shimojo, Toshinori Nakayama
Publicado 2018

Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis

por Seshiru Nakazawa, Daisuke Oikawa, Ryohei Ishii, Takashi Ayaki, Hirotaka Takahashi, Hiroyuki Takeda, Ryuichiro Ishitani, Kiyoko Kamei, Izumi Takeyoshi, Hideshi Kawakami, Kazuhiro Iwai, Izuho Hatada, Tatsuya Sawasaki, Hidefumi Ito, Osamu Nureki, Fuminori Tokunaga
Publicado 2016

Serial femtosecond crystallography structure of cytochrome c oxidase at room temperature

por Rebecka Andersson, Cecilia Safari, Robert Dods, Eriko Nango, Rie Tanaka, Ayumi Yamashita, Takanori Nakane, Kensuke Tono, Yasumasa Joti, Petra Båth, Elin Dunevall, Robert Bosman, Osamu Nureki, So Iwata, Richard Neutze, Gisela Brändén
Publicado 2017

ATP-dependent modulation of MgtE in Mg2+ homeostasis

por Atsuhiro Tomita, Mingfeng Zhang, Fei Jin, Wenhui Zhuang, Hironori Takeda, Tatsuro Maruyama, Masanori Osawa, Ken-ichi Hashimoto, Hisashi Kawasaki, Koichi Ito, Naoshi Dohmae, Ryuichiro Ishitani, Ichio Shimada, Zhiqiang Yan, Motoyuki Hattori, Osamu Nureki
Publicado 2017