Na+/H+ exchangers induce autophagy in neurons and inhibit polyglutamine-induced aggregate formation.

por Kazuya Togashi, Shuji Wakatsuki, Akiko Furuno, Shinji Tokunaga, Yoshitaka Nagai, Toshiyuki Araki
Publicado 2013

Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG

por Seiya Oura, Taichi Noda, Naoko Morimura, Seiji Hitoshi, Hiroshi Nishimasu, Yoshitaka Nagai, Osamu Nureki, Masahito Ikawa
Publicado 2021

Small molecule targeting r(UGGAA) n disrupts RNA foci and alleviates disease phenotype in Drosophila model

por Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
Publicado 2021