Structural Insights into the Azole Resistance of the <i>Candida albicans</i> Darlington Strain Using <i>Saccharomyces cerevisiae</i> Lanosterol 14α-Demethylase as a Surrogate

Target-based azole resistance in <i>Candida albicans</i> involves overexpression of the <i>ERG11</i> gene encoding lanosterol 14α-demethylase (LDM), and/or the presence of single or multiple mutations in this enzyme. Overexpression of <i>Candida albicans</i> LDM (...

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Autores principales: Danyon O. Graham, Rajni K. Wilson, Yasmeen N. Ruma, Mikhail V. Keniya, Joel D. A. Tyndall, Brian C. Monk
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/2fb14a794e4d4733aafc6a6df72d6c0b
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