RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2

RALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification.

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Autores principales: Xia Wang, Jin Wang, Yu-Man Tsui, Chaoran Shi, Ying Wang, Xin Zhang, Qian Yan, Miao Chen, Chen Jiang, Yun-Fei Yuan, Chun-Ming Wong, Ming Liu, Zeng-yu Feng, Honglin Chen, Irene Oi Lin Ng, Lingxi Jiang, Xin-Yuan Guan
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2fb80e31fc6b42d4945a5ded63e83e44
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spelling oai:doaj.org-article:2fb80e31fc6b42d4945a5ded63e83e442021-12-02T13:14:59ZRALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β210.1038/s41467-021-21828-72041-1723https://doaj.org/article/2fb80e31fc6b42d4945a5ded63e83e442021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21828-7https://doaj.org/toc/2041-1723RALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification.Xia WangJin WangYu-Man TsuiChaoran ShiYing WangXin ZhangQian YanMiao ChenChen JiangYun-Fei YuanChun-Ming WongMing LiuZeng-yu FengHonglin ChenIrene Oi Lin NgLingxi JiangXin-Yuan GuanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xia Wang
Jin Wang
Yu-Man Tsui
Chaoran Shi
Ying Wang
Xin Zhang
Qian Yan
Miao Chen
Chen Jiang
Yun-Fei Yuan
Chun-Ming Wong
Ming Liu
Zeng-yu Feng
Honglin Chen
Irene Oi Lin Ng
Lingxi Jiang
Xin-Yuan Guan
RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
description RALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification.
format article
author Xia Wang
Jin Wang
Yu-Man Tsui
Chaoran Shi
Ying Wang
Xin Zhang
Qian Yan
Miao Chen
Chen Jiang
Yun-Fei Yuan
Chun-Ming Wong
Ming Liu
Zeng-yu Feng
Honglin Chen
Irene Oi Lin Ng
Lingxi Jiang
Xin-Yuan Guan
author_facet Xia Wang
Jin Wang
Yu-Man Tsui
Chaoran Shi
Ying Wang
Xin Zhang
Qian Yan
Miao Chen
Chen Jiang
Yun-Fei Yuan
Chun-Ming Wong
Ming Liu
Zeng-yu Feng
Honglin Chen
Irene Oi Lin Ng
Lingxi Jiang
Xin-Yuan Guan
author_sort Xia Wang
title RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
title_short RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
title_full RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
title_fullStr RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
title_full_unstemmed RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
title_sort ralyl increases hepatocellular carcinoma stemness by sustaining the mrna stability of tgf-β2
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2fb80e31fc6b42d4945a5ded63e83e44
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