RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2

RALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification.

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Main Authors:	Xia Wang, Jin Wang, Yu-Man Tsui, Chaoran Shi, Ying Wang, Xin Zhang, Qian Yan, Miao Chen, Chen Jiang, Yun-Fei Yuan, Chun-Ming Wong, Ming Liu, Zeng-yu Feng, Honglin Chen, Irene Oi Lin Ng, Lingxi Jiang, Xin-Yuan Guan
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/2fb80e31fc6b42d4945a5ded63e83e44
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spelling	oai:doaj.org-article:2fb80e31fc6b42d4945a5ded63e83e442021-12-02T13:14:59ZRALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β210.1038/s41467-021-21828-72041-1723https://doaj.org/article/2fb80e31fc6b42d4945a5ded63e83e442021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21828-7https://doaj.org/toc/2041-1723RALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification.Xia WangJin WangYu-Man TsuiChaoran ShiYing WangXin ZhangQian YanMiao ChenChen JiangYun-Fei YuanChun-Ming WongMing LiuZeng-yu FengHonglin ChenIrene Oi Lin NgLingxi JiangXin-Yuan GuanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xia Wang Jin Wang Yu-Man Tsui Chaoran Shi Ying Wang Xin Zhang Qian Yan Miao Chen Chen Jiang Yun-Fei Yuan Chun-Ming Wong Ming Liu Zeng-yu Feng Honglin Chen Irene Oi Lin Ng Lingxi Jiang Xin-Yuan Guan RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
description	RALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification.
format	article
author	Xia Wang Jin Wang Yu-Man Tsui Chaoran Shi Ying Wang Xin Zhang Qian Yan Miao Chen Chen Jiang Yun-Fei Yuan Chun-Ming Wong Ming Liu Zeng-yu Feng Honglin Chen Irene Oi Lin Ng Lingxi Jiang Xin-Yuan Guan
author_facet	Xia Wang Jin Wang Yu-Man Tsui Chaoran Shi Ying Wang Xin Zhang Qian Yan Miao Chen Chen Jiang Yun-Fei Yuan Chun-Ming Wong Ming Liu Zeng-yu Feng Honglin Chen Irene Oi Lin Ng Lingxi Jiang Xin-Yuan Guan
author_sort	Xia Wang
title	RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
title_short	RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
title_full	RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
title_fullStr	RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
title_full_unstemmed	RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
title_sort	ralyl increases hepatocellular carcinoma stemness by sustaining the mrna stability of tgf-β2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2fb80e31fc6b42d4945a5ded63e83e44
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RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2

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