Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D<sub>3</sub> Analogues and Their Stability to hCYP24A1-Dependent Catabolism

Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D<sub>3</sub> Analogues and Their Stability to hCYP24A1-Dependent Catabolism

Two 24-fluoro-25-hydroxyvitamin D<sub>3</sub> analogues (<b>3</b>,<b>4</b>) were synthesized in a convergent manner. The introduction of a stereocenter to the vitamin D<sub>3</sub> side-chain C24 position was achieved via Sharpless dihydroxylation, and...

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Bibliographic Details
Main Authors: Fumihiro Kawagoe, Sayuri Mototani, Kaori Yasuda, Hiroki Mano, Toshiyuki Sakaki, Atsushi Kittaka
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
human CYP24A1
synthesis
vitamin D<sub>3</sub> metabolite
24-fluoro-25-hydroxyvitamin D<sub>3</sub> analogues
Sharpless dihydroxylation
Biology (General)
QH301-705.5
Chemistry
QD1-999
Online Access:https://doaj.org/article/2fbcff291b1f4b25a493701f37d86ed8
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https://doaj.org/article/2fbcff291b1f4b25a493701f37d86ed8

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