Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents

Tuberculosis (TB) remains one of the world’s deadliest communicable diseases, novel anti-TB agents are urgently needed due to severe drug resistance and the co-epidemic of TB/HIV. Here, the authors show that anti-mycobacterial ilamycin congeners bearing unusual structural units possess extremely pot...

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Autores principales:	Junying Ma, Hongbo Huang, Yunchang Xie, Zhiyong Liu, Jin Zhao, Chunyan Zhang, Yanxi Jia, Yun Zhang, Hua Zhang, Tianyu Zhang, Jianhua Ju
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2fdc0cee55b14abf9e63f17c5c93ec08
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spelling	oai:doaj.org-article:2fdc0cee55b14abf9e63f17c5c93ec082021-12-02T17:06:31ZBiosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents10.1038/s41467-017-00419-52041-1723https://doaj.org/article/2fdc0cee55b14abf9e63f17c5c93ec082017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00419-5https://doaj.org/toc/2041-1723Tuberculosis (TB) remains one of the world’s deadliest communicable diseases, novel anti-TB agents are urgently needed due to severe drug resistance and the co-epidemic of TB/HIV. Here, the authors show that anti-mycobacterial ilamycin congeners bearing unusual structural units possess extremely potent anti-tuberculosis activities.Junying MaHongbo HuangYunchang XieZhiyong LiuJin ZhaoChunyan ZhangYanxi JiaYun ZhangHua ZhangTianyu ZhangJianhua JuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junying Ma Hongbo Huang Yunchang Xie Zhiyong Liu Jin Zhao Chunyan Zhang Yanxi Jia Yun Zhang Hua Zhang Tianyu Zhang Jianhua Ju Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents
description	Tuberculosis (TB) remains one of the world’s deadliest communicable diseases, novel anti-TB agents are urgently needed due to severe drug resistance and the co-epidemic of TB/HIV. Here, the authors show that anti-mycobacterial ilamycin congeners bearing unusual structural units possess extremely potent anti-tuberculosis activities.
format	article
author	Junying Ma Hongbo Huang Yunchang Xie Zhiyong Liu Jin Zhao Chunyan Zhang Yanxi Jia Yun Zhang Hua Zhang Tianyu Zhang Jianhua Ju
author_facet	Junying Ma Hongbo Huang Yunchang Xie Zhiyong Liu Jin Zhao Chunyan Zhang Yanxi Jia Yun Zhang Hua Zhang Tianyu Zhang Jianhua Ju
author_sort	Junying Ma
title	Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents
title_short	Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents
title_full	Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents
title_fullStr	Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents
title_full_unstemmed	Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents
title_sort	biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2fdc0cee55b14abf9e63f17c5c93ec08
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Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents

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