Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2

Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2

How both BMP and Wnt signalling pathways regulate lineage specification early in development is unclear. Here, the authors show that endoglin via Jdp2, an AP-1 family member, modulates BMP and Wnt signalling to commit mesodermal progenitors to a haematopoietic fate at the expense of the cardiac line...

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Autores principales: June Baik, Alessandro Magli, Naoyuki Tahara, Scott A. Swanson, Naoko Koyano-Nakagawa, Luciene Borges, Ron Stewart, Daniel J. Garry, Yasuhiko Kawakami, James A. Thomson, Rita C. R. Perlingeiro
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/2ffd9d9f384f4d06b3c823151dd71c1e
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https://doaj.org/article/2ffd9d9f384f4d06b3c823151dd71c1e

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