Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2

How both BMP and Wnt signalling pathways regulate lineage specification early in development is unclear. Here, the authors show that endoglin via Jdp2, an AP-1 family member, modulates BMP and Wnt signalling to commit mesodermal progenitors to a haematopoietic fate at the expense of the cardiac line...

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Autores principales:	June Baik, Alessandro Magli, Naoyuki Tahara, Scott A. Swanson, Naoko Koyano-Nakagawa, Luciene Borges, Ron Stewart, Daniel J. Garry, Yasuhiko Kawakami, James A. Thomson, Rita C. R. Perlingeiro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ffd9d9f384f4d06b3c823151dd71c1e
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spelling	oai:doaj.org-article:2ffd9d9f384f4d06b3c823151dd71c1e2021-12-02T17:31:47ZEndoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP210.1038/ncomms131012041-1723https://doaj.org/article/2ffd9d9f384f4d06b3c823151dd71c1e2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13101https://doaj.org/toc/2041-1723How both BMP and Wnt signalling pathways regulate lineage specification early in development is unclear. Here, the authors show that endoglin via Jdp2, an AP-1 family member, modulates BMP and Wnt signalling to commit mesodermal progenitors to a haematopoietic fate at the expense of the cardiac lineage.June BaikAlessandro MagliNaoyuki TaharaScott A. SwansonNaoko Koyano-NakagawaLuciene BorgesRon StewartDaniel J. GarryYasuhiko KawakamiJames A. ThomsonRita C. R. PerlingeiroNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q June Baik Alessandro Magli Naoyuki Tahara Scott A. Swanson Naoko Koyano-Nakagawa Luciene Borges Ron Stewart Daniel J. Garry Yasuhiko Kawakami James A. Thomson Rita C. R. Perlingeiro Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2
description	How both BMP and Wnt signalling pathways regulate lineage specification early in development is unclear. Here, the authors show that endoglin via Jdp2, an AP-1 family member, modulates BMP and Wnt signalling to commit mesodermal progenitors to a haematopoietic fate at the expense of the cardiac lineage.
format	article
author	June Baik Alessandro Magli Naoyuki Tahara Scott A. Swanson Naoko Koyano-Nakagawa Luciene Borges Ron Stewart Daniel J. Garry Yasuhiko Kawakami James A. Thomson Rita C. R. Perlingeiro
author_facet	June Baik Alessandro Magli Naoyuki Tahara Scott A. Swanson Naoko Koyano-Nakagawa Luciene Borges Ron Stewart Daniel J. Garry Yasuhiko Kawakami James A. Thomson Rita C. R. Perlingeiro
author_sort	June Baik
title	Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2
title_short	Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2
title_full	Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2
title_fullStr	Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2
title_full_unstemmed	Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2
title_sort	endoglin integrates bmp and wnt signalling to induce haematopoiesis through jdp2
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2ffd9d9f384f4d06b3c823151dd71c1e
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Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2

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